DL-alpha-Tocopherol
Based on 7 publication(s) in Google Scholar
DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB.
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- Pureté: 99.57%
- CAS No.: 10191-41-0
- Formule: C29H50O2
- Masse moléculaire:430.71
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Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Publications Citing Use of MedChemExpress (MCE) DL-alpha-Tocopherol
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Acta Pharm Sin B. 2025 Jul;15(7):3788-3804. [Abstract]
- Cell Death Dis. 2018 Aug 28;9(9):847. [Abstract]
- J Agric Food Chem. 2023 Feb 15;71(6):2745-2761. [Abstract]
- Int J Mol Sci. 2025 Feb 5;26(3):1334. [Abstract]
- SSRN. 2025 Mar 31.
- Res Sq. 2024 Sep 12:rs.3.rs-5065904. [Abstract]
Customer Validation & Images
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Cell Proliferation/Viability Assay
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
>100 μM
Compound: 10b
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Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as increase in amyloid beta 38 generation after 24 hrs by ELISA
Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as increase in amyloid beta 38 generation after 24 hrs by ELISA
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[PMID: 23707256] |
| CHO | IC50 |
>100 μM
Compound: 10b
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Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as decrease in amyloid beta 40 generation after 24 hrs by ELISA
Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as decrease in amyloid beta 40 generation after 24 hrs by ELISA
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[PMID: 23707256] |
| CHO | IC50 |
>100 μM
Compound: 10b
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Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as decrease in amyloid beta 42 generation after 24 hrs by ELISA
Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as decrease in amyloid beta 42 generation after 24 hrs by ELISA
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[PMID: 23707256] |
DL-alpha-Tocopherol (0.1-1 mM, 0-12 days) inhibits the proliferation of cancer cell OCIM-1, HEL and MCF-7, inhibits the DNA synthesis and induces apoptosis[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:OCIM-1, HEL and MCF-7
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Concentration:0.1-1 mM
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Incubation Time:0-12 days
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Result:Inhibited the proliferation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats models[2]
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Dosage:100 mg/kg
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Administration:iv, single dose
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Result:Inhibited iron-induced lipid peroxidation in amygdala.
Chemical Information
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CAS No. 10191-41-0
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Appearance Liquid (Density: 0.950 g/cm3 )
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Masse moléculaire 430.71
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Formule C29H50O2
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Color Light yellow to brown
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SMILES
CC1=C2C(CCC(CCCC(C)CCCC(C)CCCC(C)C)(C)O2)=C(C)C(O)=C1C
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Synonyms
DL-α-Tocopherol
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (7)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Acta Pharm Sin B
High intensity forced ultrasound-driven ferroptosis as a strategy for anti-tumor immune priming. [Abstract]2025 Jul;15(7):3788-3804. PMID: 40698150
DL-alpha-Tocopherol purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Jul;15(7):3788-3804. [Abstract]
DL-alpha-Tocopherol (VE; 20 μM; 24 h) demonstrated a significant attenuation of cytotoxicity in the HIFU, NP + H, and NP-PF-H groups in 4T1 cells.
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Cell Death Dis
Overexpression of homeodomain-interacting protein kinase 2 (HIPK2) attenuates sepsis-mediated liver injury by restoring autophagy. [Abstract]2018 Aug 28;9(9):847. PMID: 30154452
DL-alpha-Tocopherol purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Aug 28;9(9):847. [Abstract]
HIPK2 expression is upregulated by treatments with 5 μM Resveratrol, 30 μM Aspirin, 10 μM DL-alpha-Tocopherol (vitamin E), and 15 μM Ursolic acid for another 16 h after the LPS treatment, as analysed by western blotting.
DL-alpha-Tocopherol purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Aug 28;9(9):847. [Abstract]
HIPK2 expression was upregulated by treatments with 5 μM resveratrol, 30 μM aspirin, 10 μM DL-alpha-Tocopherol (vitamin E), and 15 μM ursolic acid for another 16 h after the LPS treatment, as analysed by Q-PCR.
DL-alpha-Tocopherol purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Aug 28;9(9):847. [Abstract]
DL-alpha-Tocopherol (vitamin E; 10 μM) activated the promoter of the HIPK2 gene and by maintaining the stability of the 3′-UTR.
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J Agric Food Chem
A Novel Anti-Osteoporosis Mechanism of VK2: Interfering with Ferroptosis via AMPK/SIRT1 Pathway in Type 2 Diabetic Osteoporosis. [Abstract]2023 Feb 15;71(6):2745-2761. PMID: 36719855 -
Int J Mol Sci
Synergistic Effects of a Novel Combination of Natural Compounds Prevent H2O2-Induced Oxidative Stress in Red Blood Cells. [Abstract]2025 Feb 5;26(3):1334. PMID: 39941102
DL-alpha-Tocopherol purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Feb 5;26(3):1334. [Abstract]
DL-alpha-Tocopherol (Vit E; 1-100 μM; 1 h and 30 min) combined with Curc and Vit C, showed Anti-Oxidant Effects in RBCs.
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Res Sq
BMP receptor 2 inhibition regulates mitochondrial bioenergetics to induce synergistic cell death with BCL-2 inhibitors in leukemia and NSLC cells. [Abstract]2024 Sep 12:rs.3.rs-5065904. PMID: 39315260
Solvant et solubilité
Ethanol : ≥ 100 mg/mL (232.17 mM)
DMSO : 20 mg/mL (46.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.80 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (5.80 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Kondo S, et al. Protective effect of dl-alpha-tocopherol on the cytotoxicity of ultraviolet B against human skin fibroblasts in vitro. Photodermatol Photoimmunol Photomed. 1990 Aug;7(4):173-7. [Content Brief]
[2]. Triggs WJ, et al., Effect of [dl]-alpha-tocopherol on FeCl2-induced lipid peroxidation in rat amygdala. Neurosci Lett. 1994 Oct 10;180(1):33-6. [Content Brief]
[3]. Sigounas G, et al., dl-alpha-tocopherol induces apoptosis in erythroleukemia, prostate, and breast cancer cells. Nutr Cancer. 1997;28(1):30-5. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / Ethanol | 1 mM | 2.3217 mL | 11.6087 mL | 23.2175 mL | 58.0437 mL |
| 5 mM | 0.4643 mL | 2.3217 mL | 4.6435 mL | 11.6087 mL | |
| 10 mM | 0.2322 mL | 1.1609 mL | 2.3217 mL | 5.8044 mL | |
| 15 mM | 0.1548 mL | 0.7739 mL | 1.5478 mL | 3.8696 mL | |
| 20 mM | 0.1161 mL | 0.5804 mL | 1.1609 mL | 2.9022 mL | |
| 25 mM | 0.0929 mL | 0.4643 mL | 0.9287 mL | 2.3217 mL | |
| 30 mM | 0.0774 mL | 0.3870 mL | 0.7739 mL | 1.9348 mL | |
| 40 mM | 0.0580 mL | 0.2902 mL | 0.5804 mL | 1.4511 mL | |
| Ethanol | 50 mM | 0.0464 mL | 0.2322 mL | 0.4643 mL | 1.1609 mL |
| 60 mM | 0.0387 mL | 0.1935 mL | 0.3870 mL | 0.9674 mL | |
| 80 mM | 0.0290 mL | 0.1451 mL | 0.2902 mL | 0.7255 mL | |
| 100 mM | 0.0232 mL | 0.1161 mL | 0.2322 mL | 0.5804 mL |
DL-alpha-Tocopherol Related Classifications
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