Dot1L-IN-7
Dot1L-IN-7 (compound 25) is a potent and selective disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 of 1.0 μM. Dot1L-IN-7 selectively killed Mixed Lineage Leukemia (MLL)-AF9 without showing any effect on the growth of E2A-HLF cells.
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- CAS No.: 2580940-76-5
- Formule: C23H27N9O2
- Masse moléculaire:461.52
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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DOT1L 1 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Bone marrow cell | IC50 |
1 μM
Compound: 25
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Antiproliferative activity against mouse bone marrow cell transformed with MLL-AF9 assessed as reduction in cell growth measured after 11 days by hemocytometry
Antiproliferative activity against mouse bone marrow cell transformed with MLL-AF9 assessed as reduction in cell growth measured after 11 days by hemocytometry
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[PMID: 31978781] |
| Bone marrow cell | IC50 |
4.2 μM
Compound: 25
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Antiproliferative activity against mouse bone marrow cell transformed with MLL-AF9 assessed as reduction in cell growth measured after 9 days by hemocytometry
Antiproliferative activity against mouse bone marrow cell transformed with MLL-AF9 assessed as reduction in cell growth measured after 9 days by hemocytometry
|
[PMID: 31978781] |
| Bone marrow cell | IC50 |
8.8 μM
Compound: 25
|
Antiproliferative activity against mouse bone marrow cell transformed with MLL-AF9 assessed as reduction in cell growth measured after 6 days by hemocytometry
Antiproliferative activity against mouse bone marrow cell transformed with MLL-AF9 assessed as reduction in cell growth measured after 6 days by hemocytometry
|
[PMID: 31978781] |
Chemical Information
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CAS No. 2580940-76-5
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Masse moléculaire 461.52
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Formule C23H27N9O2
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SMILES
CC(C)(C1=CC=C(C=C1)NC(C2=NN(C=N2)CC(NCCN3C=CC4=C3N=CN=C4N)=O)=O)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)