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Cat. No.: HY-160969

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Spiro-duocarmycin

Spiro-duocarmycin is a DNA minor groove N3-adenine alkylating agent. Spiro-duocarmycin exerts cytotoxic effects via DNA alkylation. Spiro-duocarmycin is the active spirocyclized form of seco-DUBA, which is incorporated as an inactive prodrug into the linker-drug construct of antibody-drug conjugates (ADCs). DUBA serves as an ADC payload that can be conjugated with monoclonal antibodies to synthesize antibody-drug conjugates (ADCs).

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CAS No.: 1642147-15-6
Formule: C₂₉H₂₂N₄O₄
Masse moléculaire:490.51

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Spiro-duocarmycin Chemical Structure

CAS No.: 1642147-15-6

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Activité biologique
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

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In Vitro

Spiro-duocarmycin (DUBA; Compound 3b) potently inhibits the viability of human breast cancer SK-BR-3 cells, with an IC₅₀ of 0.07 nM, and its efficacy is comparable to that of its precursor seco-DUBA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	CL
Rat^[1]	0.083 mg/kg	i.v.	1.1 h	17 L/h/kg

Chemical Information

CAS No. 1642147-15-6
Masse moléculaire 490.51
Formule C₂₉H₂₂N₄O₄
SMILES

O=C(C1=CN2C(C=CC(NC(C3=CC=C(C=C3)O)=O)=C2)=N1)N4C([C@@]5(C6=C(C)C=CC=C67)[C@](C4)([H])C5)=CC7=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Elgersma RC, et al. Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody-Drug Conjugate SYD985. Molecular pharmaceutics. 2015 Jun 01;12(6):1813-35. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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- In Vitro
Chemical Information
Pureté et documentation
Références

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Spiro-duocarmycin

Voir tous les produits spécifiques à Isoform ADC Payloads