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CMTM5 - CKLF like MARVEL transmembrane domain containing 5 Gene

Also Known as CKLFSF5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 116173

About CMTM5

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:23,376,771-23,379,772 (from NCBI)

This gene has 9 transcripts (splice variants), 107 orthologues and 14 paralogues. Biased expression in brain (RPKM 15.6), bone marrow (RPKM 1.3) and 1 other tissue.

Summary

This gene encodes a member of the chemokine-like factor superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. The encoded protein may exhibit tumor suppressor activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

CMTM5 Products (5)

mRNA	Protein	Name
NM_001037288.2	NP_001032365.1	CKLF-like MARVEL transmembrane domain-containing protein 5 isoform c
NM_001288744.2	NP_001275673.1	CKLF-like MARVEL transmembrane domain-containing protein 5 isoform d
NM_001288745.2	NP_001275674.1	CKLF-like MARVEL transmembrane domain-containing protein 5 isoform e
NM_001288746.2	NP_001275675.1	CKLF-like MARVEL transmembrane domain-containing protein 5 isoform f
NM_138460.3	NP_612469.1	CKLF-like MARVEL transmembrane domain-containing protein 5 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CMTM5 Protein Structure

MARVEL

0
100
200
223 a.a.

Protein Preferred Names	Protein Names
CKLF-like MARVEL transmembrane domain-containing protein 5	chemokine-like factor super family 5

CMTM5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	CMTM5	Q96DZ9	SUCLA2	Homo sapiens	E5KS60	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	CYP1A1	Homo sapiens	P04798	Y2H Array	25416956
Intra	CMTM5	Q96DZ9	GAD1	Homo sapiens	Q8IVA8	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	GAD1	Homo sapiens	Q8IVA8	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	VARS2	Homo sapiens	Q5ST30-3	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	VARS2	Homo sapiens	Q5ST30-3	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	TUBB	Homo sapiens	Q5SU16	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	TUBB	Homo sapiens	Q5SU16	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	TUBB	Homo sapiens	Q5SU16	Y2H Array	25416956
Intra	CMTM5	Q96DZ9	PTPN9	Homo sapiens	Q6IQ43	Y2H Array	25416956
Intra	CMTM5	Q96DZ9	PTPN9	Homo sapiens	Q6IQ43	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	TUBB	Homo sapiens	Q6P602	Y2H Array	25416956
Intra	CMTM5	Q96DZ9	TUBB	Homo sapiens	Q6P602	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	ARMC9	Homo sapiens	Q7Z3E5-2	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	ARMC9	Homo sapiens	Q7Z3E5-2	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	ARMC9	Homo sapiens	Q7Z3E5-2	Y2H Array	25416956
Intra	CMTM5	Q96DZ9	AACS	Homo sapiens	Q86V21	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	AACS	Homo sapiens	Q86V21	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	MCEE	Homo sapiens	Q96PE7	Y2H Array	31515488
Intra	CMTM5	Q96DZ9	MCEE	Homo sapiens	Q96PE7	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	SSX3	Homo sapiens	Q99909	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	NDRG4	Homo sapiens	Q9ULP0	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	NDRG4	Homo sapiens	Q9ULP0	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	ALDH18A1	Homo sapiens	P54886	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	ALDH18A1	Homo sapiens	P54886	Y2H Array	25416956
Intra	CMTM5	Q96DZ9	RNF185	Homo sapiens	Q96GF1	Y2H Array	25416956
Intra	CMTM5	Q96DZ9	RNF185	Homo sapiens	Q96GF1	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	DDA1	Homo sapiens	Q9BW61	Y2H Array	25416956
Intra	CMTM5	Q96DZ9	DDA1	Homo sapiens	Q9BW61	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	FARS2	Homo sapiens	O95363	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	FARS2	Homo sapiens	O95363	Y2H Array	25416956
Intra	CMTM5	Q96DZ9	SH3GLB1	Homo sapiens	Q9Y371	Y2H Array	25416956
Intra	CMTM5	Q96DZ9	FAM114A1	Homo sapiens	Q8IWE2	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	FAM114A1	Homo sapiens	Q8IWE2	Y2H Array	25416956
Intra	CMTM5	Q96DZ9	RMDN2	Homo sapiens	Q96LZ7	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	RMDN2	Homo sapiens	Q96LZ7	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	SNX1	Homo sapiens	Q13596	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	SNX1	Homo sapiens	Q13596	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	GLTP	Homo sapiens	Q9NZD2	Y2H Array	31515488
Intra	CMTM5	Q96DZ9	GLTP	Homo sapiens	Q9NZD2	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	ACSF2	Homo sapiens	Q96CM8	Y2H Array	31515488
Intra	CMTM5	Q96DZ9	ACSF2	Homo sapiens	Q96CM8	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	ACSF2	Homo sapiens	Q96CM8	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	ACSF2	Homo sapiens	Q96CM8	Y2H Array	25416956
Intra	CMTM5	Q96DZ9	RBFA	Homo sapiens	Q8N0V3	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	RBFA	Homo sapiens	Q8N0V3	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	SHMT2	Homo sapiens	P34897	Y2H Array	25416956
Intra	CMTM5	Q96DZ9	SHMT2	Homo sapiens	P34897	Y2H Array	29892012
Intra	CMTM5	Q96DZ9	SHMT2	Homo sapiens	P34897	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	GTF3C1	Homo sapiens	Q12789	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	GTF3C1	Homo sapiens	Q12789	Y2H Array	25416956
Intra	CMTM5	Q96DZ9	TUFM	Homo sapiens	P49411	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	TUFM	Homo sapiens	P49411	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	TUFM	Homo sapiens	P49411	Y2H Array	25416956
Intra	CMTM5	Q96DZ9	EMP3	Homo sapiens	P54852	PLA	30614533
Intra	CMTM5	Q96DZ9	EMP3	Homo sapiens	P54852	BiFC	30614533
Intra	CMTM5	Q96DZ9	ECPAS	Homo sapiens	Q5VYK3	Y2H Array	25416956
Intra	CMTM5	Q96DZ9	APOA1	Homo sapiens	P02647	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	APOA1	Homo sapiens	P02647	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	MYG1	Homo sapiens	Q9HB07	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	MYG1	Homo sapiens	Q9HB07	Y2H Array	31515488
Intra	CMTM5	Q96DZ9	SDCBP	Homo sapiens	O00560	Y2H Array	25416956
Intra	CMTM5	Q96DZ9	LMO2	Homo sapiens	P25791	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	LMO2	Homo sapiens	P25791	Y2H Array	25416956
Intra	CMTM5	Q96DZ9	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	PTPN9	Homo sapiens	P43378	Y2H Array	25416956
Intra	CMTM5	Q96DZ9	PTPN9	Homo sapiens	P43378	Y2H	21516116
Intra	CMTM5	Q96DZ9	PTPN9	Homo sapiens	P43378	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	PTPN9	Homo sapiens	P43378	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	GAD1	Homo sapiens	Q99259	Y2H	21516116
Intra	CMTM5	Q96DZ9	GAD1	Homo sapiens	Q99259	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	GAD1	Homo sapiens	Q99259	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	GAD1	Homo sapiens	Q99259	Y2H Array	25416956
Intra	CMTM5	Q96DZ9	PITPNC1	Homo sapiens	Q9UKF7	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	PITPNC1	Homo sapiens	Q9UKF7	Y2H Array	25416956
Intra	CMTM5	Q96DZ9	MTERF3	Homo sapiens	Q96E29	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	MTERF3	Homo sapiens	Q96E29	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	TIMM44	Homo sapiens	O43615	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	SPATA8	Homo sapiens	Q6RVD6	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	GAD2	Homo sapiens	Q05329	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	TPD52L3	Homo sapiens	Q96J77	Y2H Prey Pooling	25416956
Intra	CMTM5	Q96DZ9	TPD52L3	Homo sapiens	Q96J77	Validated Y2H	25416956
Intra	CMTM5	Q96DZ9	TPD52L3	Homo sapiens	Q96J77	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS02867	CMTM5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CMTM5	VGNC	VGNC:39382
Rattus norvegicus	CMTM5	RGD	RGD:1307045
Mus musculus	CMTM5	MGD	MGI:2447164
Felis catus	CMTM5	VGNC	VGNC:61002
Bos taurus	CMTM5	VGNC	VGNC:27485
Macaca mulatta	CMTM5	VGNC	VGNC:71217
Others	CMTM5	NCBI