IAG-10
IAG-10 is a selective DNA polymerase kappa (hpol κ) inhibitor with an IC50 value of 7.2 μM. IAG-10 exerts its function by disrupting the formation of the binary complex between the enzyme and DNA. IAG-10 enhances the antiproliferative and DNA-damaging activities of Temozolomide (HY-17364) in tumor cells with functional hpol κ expression. IAG-10 can be used in the research of cancers such as malignant brain tumors.
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- CAS No.: 2361305-69-1
- Formule: C21H17Cl2N5O
- Masse moléculaire:426.30
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
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DNA Polymerase |
IAG-10 (0.1-0.5 μM; 1 hour) potentiates the anti-proliferative effect of Temozolomide (HY-17364) in hpol κ-proficient HAP-1 cells but not in hpol κ-deficient cells, indicating target-dependent activity[1].
IAG-10 (0.5 μM; 1 hour) increases DNA damage in hpol κ-proficient HAP-1 cells alone and in combination with Temozolomide (HY-17364), with no effect in hpol κ-deficient cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:hpol κ-proficient (HAP-1), hpol κ-deficient (HAP-1 hpol κ KO) cells
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Concentration:0.1 μM, 0.5 μM
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Incubation Time:1 hour
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Result:Reduced colony formation by hpol κ-proficient cells at all TMZ concentrations tested when co-treated with 0.5 μM IAG-10 compared to TMZ alone.
Reduced colony formation to ~40% of untreated cells at 250 μM TMZ + 0.5 μM IAG-10, while TMZ alone allowed ~75% colony formation.
Caused no significant reduction in hpol κ-deficient cells.
Chemical Information
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CAS No. 2361305-69-1
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Masse moléculaire 426.30
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Formule C21H17Cl2N5O
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SMILES
O=C(N1C=C(C2=C1C=CC(Cl)=C2)/C=N/NC(N)=N)C3=CC=CC4=C3C=CC=C4.Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IAG-10 Related Classifications
HY-180392 Related Classifications
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