Ivermectin B1b
Based on 1 Customer Validation
Ivermectin B1b is the minor component of Ivermectin. Ivermectin, a potent anti-parasitic agent, inhibits the replication of SARS-CoV-2 in cell culture.
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- Pureté: 98.66%
- CAS No.: 70209-81-3
- Formule: C47H72O14
- Masse moléculaire:861.07
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Ivermectin and Ivermectin B1b are the most potent inhibitors of contraction and motility in both susceptible isolates (H. contortus McMaster and and O. circumcincta McMaster) also show the highest resistance ratios in both species[3].
Vermectin is a macrocyclic lactone that acts as a positive allosteric modulator of α7 nicotinic acetylcholine receptors (nAChRs) but has no modulatory activity on 5-HT3 receptors[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 70209-81-3
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Appearance Solid
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Masse moléculaire 861.07
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Formule C47H72O14
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Color White to off-white
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SMILES
CC([C@H]1O[C@]2(CC[C@@H]1C)C[C@](O3)([H])C[C@](C/C=C([C@H]([C@H](/C=C/C=C4[C@@]5(O)[C@](C=C(C)[C@@H](O)[C@@]5([H])OC/4)([H])C3=O)C)O[C@@]6([H])C[C@@H]([C@@H](O[C@@]7([H])C[C@@H]([C@@H](O)[C@H](C)O7)OC)[C@H](C)O6)OC)\C)([H])O2)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 50 mg/mL (58.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Katz N, et al. Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis. J Antibiot (Tokyo). 2017;70(5):680-684. [Content Brief]
[2]. Bray M, et al. Ivermectin and COVID-19: A report in Antiviral Research, widespread interest, an FDA warning, two letters to the editor and the authors' responses. Antiviral Res. 2020;178:104805. [Content Brief]
[3]. Demeler J, et al. Measuring the effect of avermectins and milbemycins on somatic muscle contraction of adult Haemonchus contortus and on motility of Ostertagia circumcincta in vitro. Parasitology. 2014;141(7):948-956. [Content Brief]
[4]. Collins T, et al. Nicotinic acetylcholine receptor transmembrane mutations convert ivermectin from a positive to a negative allosteric modulator. Mol Pharmacol. 2010;78(2):198-204. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1613 mL | 5.8067 mL | 11.6135 mL | 29.0336 mL |
| 5 mM | 0.2323 mL | 1.1613 mL | 2.3227 mL | 5.8067 mL | |
| 10 mM | 0.1161 mL | 0.5807 mL | 1.1613 mL | 2.9034 mL | |
| 15 mM | 0.0774 mL | 0.3871 mL | 0.7742 mL | 1.9356 mL | |
| 20 mM | 0.0581 mL | 0.2903 mL | 0.5807 mL | 1.4517 mL | |
| 25 mM | 0.0465 mL | 0.2323 mL | 0.4645 mL | 1.1613 mL | |
| 30 mM | 0.0387 mL | 0.1936 mL | 0.3871 mL | 0.9678 mL | |
| 40 mM | 0.0290 mL | 0.1452 mL | 0.2903 mL | 0.7258 mL | |
| 50 mM | 0.0232 mL | 0.1161 mL | 0.2323 mL | 0.5807 mL |
Ivermectin B1b Related Classifications
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