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Cat. No.: HY-181583

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LASSBio-2389

LASSBio-2389 is a selective ROCK2 inhibitor with an IC₅₀ of 0.051 μM and an IC₅₀ of 1.143 μM against ROCK1. LASSBio-2389 reduces the viability of MDA-MB-231 cells and inhibits cell migration. LASSBio-2389 is applicable to the research of triple-negative breast cancer.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2671377-38-9
Formule: C₁₈H₁₈N₄O₄
Masse moléculaire:354.36

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

LASSBio-2389 Chemical Structure

CAS No.: 2671377-38-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

ROCK1

1.143 μM (IC₅₀)

ROCK2

0.051 μM (IC₅₀)

Voir tous les produits spécifiques à Isoform ROCK :

In Vitro

LASSBio-2389 exhibits high passive permeability in gastrointestinal tract models, but shows no permeability in blood-brain barrier models^[1].
LASSBio-2389 (30 μM; 24 h) reduces the viability of MDA-MB-231 cells^[1].
LASSBio-2389 (0.1-100 μM; 24 h) potently inhibits the migration of MDA-MB-231 cells at concentrations as low as 0.1 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MDA-MB-231 triple-negative breast cancer cells
Concentration:

30 μM
Incubation Time:

24 h
Result:

Reduced MDA-MB-231 cell viability by 26.2% (73.8% viability relative to vehicle control).

Chemical Information

CAS No. 2671377-38-9
Masse moléculaire 354.36
Formule C₁₈H₁₈N₄O₄
SMILES

O=C(C1=CC(OC)=C(OC)C(OC)=C1)N/N=C/C2=CC(C=NN3)=C3C=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Pinheiro P S M, et al. Discovery of N-Acylhydrazone Derivatives as ROCK Inhibitors: A Journey from Virtual Screening and Structure-Based De Novo Design to the Identification of ROCK2 Selective Inhibitors and Beyond. ACS Bio & Med Chem Au, 2026.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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LASSBio-2389

Voir tous les produits spécifiques à Isoform ROCK

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

LASSBio-2389 Related Classifications

HY-181583 Related Classifications