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Cat. No.: HY-11072

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MK-0359

(Synonyms: L-454,560)

MK-0359 (L-454,560) is a selective and orally active PDE4 inhibitor, and can be used for asthma and chronic obstructive pulmonary disease (COPD) research.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 346629-30-9
Formule: C₃₁H₂₉N₃O₅S₂
Masse moléculaire:587.71

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

MK-0359 Chemical Structure

CAS No.: 346629-30-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- Essai clinique
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

MK-0359 (L-454,560) is a selective and orally active PDE4 inhibitor, and can be used for asthma and chronic obstructive pulmonary disease (COPD) research^[1].

Voir tous les produits spécifiques à Isoform Phosphodiesterase (PDE) :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	49.9 μM Compound: 3	Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells	[PMID: 18835163]
Sf21	IC₅₀	3.9 μM Compound: 4, L-454560	Inhibition of His-tagged catalytic domain Trypanosoma brucei brucei PDEB2 expressed in baculovirus infected insect Sf21 cells Inhibition of His-tagged catalytic domain Trypanosoma brucei brucei PDEB2 expressed in baculovirus infected insect Sf21 cells	[PMID: 22023548]
Sf21	IC₅₀	8.8 μM Compound: 4, L-454560	Inhibition of His-tagged catalytic domain Trypanosoma brucei brucei PDEB1 expressed in baculovirus infected insect Sf21 cells Inhibition of His-tagged catalytic domain Trypanosoma brucei brucei PDEB1 expressed in baculovirus infected insect Sf21 cells	[PMID: 22023548]
Sf9	IC₅₀	1.4 nM Compound: 3	Intrinsic inhibition of GST-fused human PDE4A expressed in SF9 cells Intrinsic inhibition of GST-fused human PDE4A expressed in SF9 cells	[PMID: 18835163]
Sf9	IC₅₀	3 nM Compound: 1, L-454560	Inhibition of PDE4 expressed in SF9 cells Inhibition of PDE4 expressed in SF9 cells	[PMID: 18207397]

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 346629-30-9
Masse moléculaire 587.71
Formule C₃₁H₂₉N₃O₅S₂
SMILES

O=S(C1=CC=C(/C(C2=NC(C)=NO2)=C\C3=CC(C4=C5N=CC=CC5=CC(C(S(=O)(C)=O)(C)C)=C4)=CC=C3)C=C1)(C)=O
Synonyms

L-454,560
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Lu S, et al. Randomized, placebo-controlled study of a selective PDE4 inhibitor in the treatment of asthma. Respir Med. 2009 Mar;103(3):342-7. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Activité biologique
- Description
- Essai clinique
Chemical Information
Pureté et documentation
Références

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MK-0359

Voir tous les produits spécifiques à Isoform Phosphodiesterase (PDE)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

MK-0359 Related Classifications

HY-11072 Related Classifications