Nerelimomab
Based on 1 publication(s) in Google Scholar
Nerelimomab (BAYX1351) is an anti-TNF-α antibody. Nerelimomab can be used for research of sepsis.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 162774-06-3
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Nerelimomab
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Activité biologique
Human IgG1 kappa
Human
TNF
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Baboon model of recurrent bacteremia (Challenged with E.coli)[1]
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Dosage:7.5 mg/kg
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Administration:i.v. infusion
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Result:Improved organ function and attenuated cytokine and plasminogen activator inhibitor release.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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IgG1-nd
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 162774-06-3
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SMILES
[Nerelimomab]
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Synonyms
BAYX1351
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Pharmaceuticals (Basel)
Nerelimomab Alleviates Capsaicin-Induced Acute Lung Injury by Inhibiting TNF Signaling and Apoptosis. [Abstract]2024 Dec 15;17(12):1694. PMID: 39770536
Pureté et documentation
Références
[1]. Schlag G, et al. Anti-tumor necrosis factor antibody treatment of recurrent bacteremia in a baboon model. Shock. 1994 Jul;2(1):10-8; discussion 19-22. [Content Brief]
[2]. Cohen J, et al. INTERSEPT: an international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group. Crit Care Med. 1996 Sep;24(9):1431-40. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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