CTLA-4
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4, CD152) is a founding immune checkpoint receptor of the CD28 superfamily, expressed on activated conventional T cells and constitutively on regulatory T cells (Tregs). CTLA-4 shares its ligands B7-1 (CD80) and B7-2 (CD86) with the co-stimulator CD28 but binds them with markedly higher affinity, competitively stripping B7 molecules off antigen-presenting cells and thereby terminating CD28 co-stimulation; CTLA-4 additionally delivers cell-intrinsic inhibitory signals through its cytoplasmic YVKM motif recruiting AP-2 and SHP-2, and its trans-endocytosis of B7 depletes APC co-stimulatory capacity. CTLA-4 is essential for peripheral tolerance: germline CTLA4 haploinsufficiency causes autoimmune lymphoproliferative syndrome. Ipilimumab, the first checkpoint-blocking antibody approved in cancer (melanoma), unleashes antitumor T cells by freeing B7 for CD28 engagement, with Treg depletion in tumors contributing to efficacy.
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CTLA-4 Protéines Recombinantes (25)
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Inhibitors & Agonists (40)
CTLA-4 Protein, Human (HEK293, His)
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Cat. No.: HY-P70684
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Mouse (HEK293, Fc)
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Cat. No.: HY-P70706
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte Antigen 4; Cytotoxic T-Lymphocyte Protein 4; Alternative Protein CTLA4; GSE; Celiac Disease; CD; CD152 Antigen; Cytotoxic T-Lymphocyte-Associated Antigen 4; ALPS5; Insulin-Dependent Diabetes Mellitus 12; GRD4; Gluten-Sensitive Enteropathy; Cytotoxic T-Lymphocyte Associated Protein 4; Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen 4
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CTLA-4 Protein, Mouse (HEK293, His)
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Cat. No.: HY-P71991
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Human (HEK293)
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Cat. No.: HY-P72959
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Human (Biotinylated, HEK293, mFc-Avi)
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Cat. No.: HY-P78890
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte Antigen 4; Cytotoxic T-Lymphocyte Protein 4; Alternative Protein CTLA4; GSE; Celiac Disease; CD; CD152 Antigen; Cytotoxic T-Lymphocyte-Associated Antigen 4; ALPS5; Insulin-Dependent Diabetes Mellitus 12; GRD4; Gluten-Sensitive Enteropathy; Cytotoxic T-Lymphocyte Associated Protein 4; Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen 4
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CTLA-4 Protein, Human (HEK293, GST)
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Cat. No.: HY-P70691
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Human (HEK293, Fc)
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Cat. No.: HY-P70001
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Guinea pig (P.pastoris, His)
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Cat. No.: HY-P71986
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Rhesus Macaque (HEK293, His)
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Cat. No.: HY-P77345
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Canine (HEK293, His)
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Cat. No.: HY-P75320
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Rat (HEK293, His)
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Cat. No.: HY-P74215
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Rat (HEK293, Fc)
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Cat. No.: HY-P74216
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte Antigen 4; Cytotoxic T-Lymphocyte Protein 4; Alternative Protein CTLA4; GSE; Celiac Disease; CD; CD152 Antigen; Cytotoxic T-Lymphocyte-Associated Antigen 4; ALPS5; Insulin-Dependent Diabetes Mellitus 12; GRD4; Gluten-Sensitive Enteropathy; Cytotoxic T-Lymphocyte Associated Protein 4; Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen 4
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CTLA-4 Protein, Human (HEK293, mFc)
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Cat. No.: HY-P704553
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Human (Biotinylated, HEK293, hFc-Avi)
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Cat. No.: HY-P72363
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Human (Biotinylated, HEK293, His-Avi)
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Cat. No.: HY-P78112
Pureté: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Mouse (Biotinylated, HEK293, His-Avi)
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Cat. No.: HY-P78889
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte Antigen 4; Cytotoxic T-Lymphocyte Protein 4; Alternative Protein CTLA4; GSE; Celiac Disease; CD; CD152 Antigen; Cytotoxic T-Lymphocyte-Associated Antigen 4; ALPS5; Insulin-Dependent Diabetes Mellitus 12; GRD4; Gluten-Sensitive Enteropathy; Cytotoxic T-Lymphocyte Associated Protein 4; Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen 4
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CTLA-4 Protein, Rhesus Macaque (HEK293, Fc)
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Cat. No.: HY-P72958
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Mouse (Biotinylated, HEK293, His)
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Cat. No.: HY-P75317
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi)
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Cat. No.: HY-P78891
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Canine (HEK293, Fc)
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Cat. No.: HY-P75321
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
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Capetin (28-54), human
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- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
