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Cat. No.: HY-P99883

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Biologically Validated

Romilkimab

Name: Romilkimab
Brand: MedChemExpress
SKU: HY-P99883
Price: 530.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: SAR156597)

Avis client

Based on 1 Customer Validation

Romilkimab (SAR156597) is a humanized IG antibody that specifically targets IL-4 and IL-13. Romilkimab can be used for the research of diffuse cutaneous systemic sclerosis.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté: 99.01%
CAS No.: 1399584-78-1
Masse moléculaire:197.9 kDa

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Romilkimab Chemical Structure

CAS No.: 1399584-78-1

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Essai clinique
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Verified Bioactivity
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Romilkimab (SAR156597) is a humanized IG antibody that specifically targets IL-4 and IL-13. Romilkimab can be used for the research of diffuse cutaneous systemic sclerosis^[1]^[2]^[3].

Isotype

[VH-VH'-H-Gamma4_VL-VL'-C-kappa]-dimer

Recommend Isotype Controls

Human IgG4 (S228P) kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target^[1]

IL-13

IL-4

Voir tous les produits spécifiques à Isoform Interleukin Related :

In Vitro

Romilkimab acts as a selective immunosuppressant in systemic sclerosis (SSc), where it exerts anti-fibrotic effects through targeted neutralization of both the IL-4 and IL-13 pathways^[1].
Romilkimab reduced thymus and activation-regulated chemokine (TARC/CCL17) levels associated with idiopathic pulmonary fibrosis (IPF)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

3565 [NCBI] & 3596 [NCBI]

Accession

P05112 & P35225

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

[VH-VH'-H-Gamma4_VL-VL'-C-kappa]-dimer

Application

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized IL-13 Protein, Human (HEK293, His, HY-P70568) can bind Romilkimab. The EC₅₀ for this effect is 15.86 ng/mL.
Immobilized IL-4 Protein, Human (HY-P70445) can bind Romilkimab. The EC₅₀ for this effect is 931.1 ng/mL.

Chemical Information

CAS No. 1399584-78-1
Appearance Liquid
Masse moléculaire 197.9 kDa
Color Colorless to light yellow
SMILES

[Romilkimab]
Synonyms

SAR156597
Livraison

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (257 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Références

[1]. Fernández-Lázaro D, et al. Impact of Innovative Treatment Using Biological Drugs for the Modulation of Diffuse Cutaneous Systemic Sclerosis: A Systematic Review. Medicina (Kaunas). 2023 Jan 27;59(2):247. [Content Brief]

[2]. Allanore Y, et al. A randomised, double-blind, placebo-controlled, 24-week, phase II, proof-of-concept study of romilkimab (SAR156597) in early diffuse cutaneous systemic sclerosis. Ann Rheum Dis. 2020;79(12):1600-1607. [Content Brief]

[3]. Raghu G, et al. SAR156597 in idiopathic pulmonary fibrosis: a phase 2 placebo-controlled study (DRI11772). Eur Respir J. 2018;52(6):1801130. Published 2018 Dec 13. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Activité biologique
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Essai clinique
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Biological Activity
Chemical Information
Pureté et documentation
Références

1/16

[VH-VH'-H-Gamma4_VL-VL'-C-kappa]-dimer
1/16

Immobilized IL-13 Protein, Human (HEK293, His, HY-P70568) can bind Romilkimab. The EC₅₀ for this effect is 15.86 ng/mL.
1/16

Immobilized IL-4 Protein, Human (HY-P70445) can bind Romilkimab. The EC₅₀ for this effect is 931.1 ng/mL.
1/16

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Romilkimab

HOLO Human Interleukin-2 (IL-2) Detection Kit

Protein A Agarose

Bradford Protein Assay Kit

DPBS Buffer (1×)

PBS Buffer (1×)

Cytotoxicity LDH Assay Kit

Voir tous les produits spécifiques à Isoform Interleukin Related