SPR38
SPR38 is a potent SARS-CoV-2 main protease inhibitor, with a Ki of 0.260 μM. SPR38 also inhibits hCatL and hCatB, with Ki values of 1.92 μM and 11.1 μM, respectively.
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- Formule: C24H33N3O5
- Masse moléculaire:443.54
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Voir tous les produits spécifiques à Isoform Cathepsin
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Activité biologique
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cathepsin L 1.92 ± 0.1 μM (IC50) |
Cathepsin B 11.1 ± 1.2 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| Huh-7 | CC50 |
60.9 μM
Compound: SPR38
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Cytotoxicity against human Huh-7 cells overexpressing human ACE2 assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against human Huh-7 cells overexpressing human ACE2 assessed as reduction in cell viability incubated for 24 hrs by MTT assay
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[PMID: 36549112] |
SPR38 shows no inhibition at 100 μM against SARS-CoV-2 papain-like protease (PLpro), which plays a crucial role in processing viral polyproteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 443.54
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Formule C24H33N3O5
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SMILES
O=C(OCC1=CC=CC=C1)N[C@@H](CCCC)C(N[C@H](/C=C/C(C)=O)C[C@H]2C(NCC2)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SPR38 Related Classifications
HY-152222 Related Classifications
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