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TRX-518

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Based on 1 Customer Validation

TRX-518 is a humanized agylcosyl IgG1 anti-GITR mAb, , and is a GITR agonist. TRX-518 binds to the extracellular domain of human GITR, abrogates Treg-mediated suppression. TRX-518 increases effector T cell activation and pro-inflammatory cytokine production, reduces circulating and intratumor Treg frequencies. TRX-518 destabilizes Treg phenotype via Foxp3 downregulation and T-bet upregulation. TRX-518 can be used for the research of solid tumors[1][2][3].

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  • Pureté: 98.58%
  • Masse moléculaire:145.26 kDa
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for TRX-518
  • Experimental Validation Results for TRX-518
  • TRX-518 Chemical Structure
    TRX-518 Chemical Structure
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TRX-518 Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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  • 1/16

    Flow cytometric analysis of 1X106 Jurkat cells with TRX-518 (HY-P991180, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Immobilized Human GITR/TNFRSF18 Protein, His Tag can bind TRX-518. The EC50 for this effect is 97.76 ng/mL.

  • TRX-518 Chemical Structure
    1/16
  • TRX-518
  • Flow cytometric analysis of 1X106 Jurkat cells with TRX-518 (HY-P991180, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Immobilized Human GITR/TNFRSF18 Protein, His Tag can bind TRX-518. The EC50 for this effect is 97.76 ng/mL.