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Cat. No.: HY-158047

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UNC8900

UNC8900 is a STING PROTAC degrader with a DC₅₀ of 0.924 μM. UNC8900 binds to the Von Hippel-Lindau E3 ubiquitin ligase and recruits it to activated STING for ubiquitination and subsequent degradation. UNC8900 can be used in related research on renal cell carcinoma.
(Pink: STING ligand (HY-184545); Blue: VHL ligand (HY-138678B); Black: linker).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 3094059-45-4
Formule: C₇₅H₉₉N₁₇O₁₅S
Masse moléculaire:1510.76

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

UNC8900 Chemical Structure

CAS No.: 3094059-45-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

UNC8900 is a STING PROTAC degrader with a DC₅₀ of 0.924 μM. UNC8900 binds to the Von Hippel-Lindau E3 ubiquitin ligase and recruits it to activated STING for ubiquitination and subsequent degradation. UNC8900 can be used in related research on renal cell carcinoma^[1]. (Pink: STING ligand (HY-184545); Blue: VHL ligand (HY-138678B); Black: linker).

Voir tous les produits spécifiques à Isoform PROTACs :

Cellular Effect

Cell Line	Type	Value	Description	References
CAKI-1	DC₅₀	0.924 μM	STING protein degradation in human Caki-1 renal cell carcinoma cells incubated for 24 hrs measured by immunoblot analysis of whole cell lysates. STING protein degradation in human Caki-1 renal cell carcinoma cells incubated for 24 hrs measured by immunoblot analysis of whole cell lysates.	37183204

In Vitro

UNC8900 (8 h) produces clear dose-dependent STING degradation in HKC-8 kidney cells after 8 hours^[1].
UNC8900 (0-31.6 μM; 24 h) potently degrades STING with a DC₅₀ of 0.924 μM and a maximum degradation level of 97.65% in Caki-1 renal cell carcinoma cells following 24 hour incubation^[1].
UNC8900 (3 μM; 0-24 h) mediates very rapid STING degradation, with measurable STING protein reduction detected as early as 2 hours post-incubation in Caki-1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HKC-8 human immortalized kidney cells
Concentration:

Dose range
Incubation Time:

8 h
Result:

Induces robust, dose-dependent reduction of STING protein expression in HKC-8 cells.

Western Blot Analysis^[1]

Cell Line:

Caki-1 human renal cell carcinoma cells
Concentration:

0-31.6 μM
Incubation Time:

24 h
Result:

Degrades STING protein with a DC50 of 0.924 μM, and achieves a maximum STING degradation (Dmax) value of 97.65% after 24 hours.

Western Blot Analysis^[1]

Cell Line:

Caki-1 human renal cell carcinoma cells
Concentration:

3 μM
Incubation Time:

0, 2, 4, 8, 12, 24 h
Result:

Results in robust STING degradation occurring within 2 hours, and near-complete STING loss is observed by 8 hours.

Chemical Information

CAS No. 3094059-45-4
Masse moléculaire 1510.76
Formule C₇₅H₉₉N₁₇O₁₅S
SMILES

O=C(C1=CC2=C(N(C(NC(C3=CC(C)=NN3CC)=O)=N2)C/C=C/CN4C(NC(C5=CC(C)=NN5CC)=O)=NC6=C4C(OCCCN7CCOCC7)=CC(C(N)=O)=C6)C(OC)=C1)NCCOCCOCCOCCOCCC(N[C@H](C(C)(C)C)C(N8[C@@H](C[C@@H](O)C8)C(NCC9=CC=C(C%10=C(N=CS%10)C)C=C9)=O)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhu Z, et al. Development of VHL-recruiting STING PROTACs that suppress innate immunity. Cellular and molecular life sciences : CMLS. 2023 May 14;80(6):149. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références

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UNC8900

Voir tous les produits spécifiques à Isoform PROTACs

Activité biologique

Description

Cellular Effect

In Vitro

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

UNC8900 Related Classifications

HY-158047 Related Classifications

Bioz

Keywords

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