CYP11A1-IN-4
CYP11A1-IN-4 is a CYP11A1 inhibitor with an estimated IC50 of 25.2 nM. CYP11A1-IN-4 shows no obvious cytotoxicity against KGN cells. CYP11A1-IN-4 exhibits weak inhibition of CYP2D6 in microsomal off-target screening. CYP11A1-IN-4 demonstrates high in vitro metabolic stability in human liver microsomes. CYP11A1-IN-4 can be used for research on castration-resistant prostate cancer.
For research use only. We do not sell to patients.
- Formula: C20H24N2O5S
- Molecular Weight:404.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
CYP11A1 25.2 nM (IC50) |
CYP2D6 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KGN | IC50 |
25.2 nM
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Inhibition of CYP11A1 in KGN human ovarian granulosa-like tumor cells assessed by pregnenolone levels in culture supernatant in a concentration-response assay.
Inhibition of CYP11A1 in KGN human ovarian granulosa-like tumor cells assessed by pregnenolone levels in culture supernatant in a concentration-response assay.
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j.bmcl.2026.130792 |
In Vitro
CYP11A1-IN-4 (1.4-3000 nM) shows no obvious cytotoxicity in KGN cells at activity-related concentrations[1].
CYP11A1-IN-4 (10 μM) shows low numerical inhibition of major drug-metabolizing CYPs in human liver microsomes, with the highest inhibition rate of 24.0% against CYP2D6[1].
CYP11A1-IN-4 shows high in vitro microsomal stability, with t1/2 > 186.4 min and in vitro CLint < 7.4 μL/min/mg protein[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 404.48
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Formula C20H24N2O5S
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SMILES
O=C1C=C(CN2CC(C=CC=C3)=C3C2)OC=C1OCC4CN(S(=O)(CC)=O)C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CYP11A1-IN-4 Related Classifications
HY-190672 Related Classifications
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