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Art. -Nr.: HY-182533

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LN5972

LN5972 is a selective ACKR3 agonist with an EC₅₀ of 3.40 μM, showing higher selectivity for ACKR3 over CXCR4. LN5972 induces β-arrestin recruitment to ACKR3/CXCR7. LN5972 reduces the surface expression of P-selectin. LN5972 is applicable to studies related to platelet-mediated thrombosis.

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CAS. Nr.: 3035425-93-2
Formel: C₁₉H₃₀N₆O₃S
Molecular Weight:422.54

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

LN5972 Chemical Structure

CAS. Nr.: 3035425-93-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

ACKR3

3.40 μM (EC₅₀)

Alle CXCR Isoform-spezifische Produkte anzeigen :

In Vitro

LN5972 (0.3 nM-100 μM) acts as a superagonist for ACKR3 in HEK293T cells, inducing β-arrestin recruitment with an EC₅₀ of 3.40 μM and a maximal efficacy 161% that of CXCL12^[1].
LN5972 (100 μM; 15 min preincubation) reduces CRP-XL-induced P-selectin expression by 76% in human platelet-rich plasma^[1].
LN5972 (0.3 nM-100 μM) is selective for ACKR3 and shows no activity at CXCR4 in HEK293T cells^[1].
LN5972 shows high metabolic stability in human liver microsomes (87% remaining at 120 min) and reduced stability in mouse liver microsomes^[1].
LN5972 (up to 100 μM; 72 h) is non-cytotoxic to THP1 and HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anwendung

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS. Nr. 3035425-93-2
Molecular Weight 422.54
Formel C₁₉H₃₀N₆O₃S
SMILES

O=C(N1CCN(CCCNC2=NN3C(C=C(CC)N=C3S2)=O)CC1)OC(C)(C)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Bayrak A, et al. Discovery and Development of First-in-Class ACKR3/CXCR7 Superagonists for Platelet Degranulation Modulation. J Med Chem. 2022;65(19):13365-13384. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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