Myelopeptide-2
Myelopeptide-2 is a peptide originally isolated from the supernatant of porcine bone marrow cell cultures, can restore mitogenic reactivity of human T lymphocytes inhibited by HL-60 leukemia cells or measles virus conditions. Myelopeptide-2 also recover depressed interleukin-2 (IL-2) synthesis and interleukin-2 receptor (IL-2R) expression. Myelopeptide-2 involves in immunity homeostasis, is perspective to be applied in antitumor and antivirus research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 137833-31-9
- Formel: C41H57N7O8
- Molecular Weight:775.93
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
|
IL-2 |
Myelopeptide-2 (1 ng/mL-0.1 mg/mL; 72 h) restores phytohemagglutinin (PHA, 2.5 mg/mL)-induced proliferation of human peripheral blood T lymphocytes[1].
Myelopeptide-2 (0.1 mg/mL and 1 mg/mL; 1-3 d) increases the level of the reduced IL-2 synthesis in human T lymphocytes damaged by HL-60 or measles virus[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male BALB/c mice (3-month-old) with spontaneous lung tumors[2]
-
Dosage:10 μg/kg; accompanied with 0.5 mg/kg Urethane (HY-B1207) or not
-
Administration:Routine injection; (1) 1 injection of MP-2 and after 7 days 3 injections of MP-2 every other day, (2) or alternating with injections of urethane (4 injections of MP-2; 3 injections of urethane+4 injections of MP-2); (3) 3 injections of MP-2 every other day or (4) alternating with injections of urethane and after 3 weeks 2 injections of MP-2 monthly with one-week interval, a total of 22 injections (25 injections of MP-2; 3 injections of urethane+25 injections of MP-2). For 20-50 weeks.
-
Result:Significantly lowered the incidence of urethane-induced lung adenomas in animals receiving 4 injections of MP-2 compared to the group receiving urethane alone or in combination with 25 injections of MP-2.
Chemical Information
-
CAS. Nr. 137833-31-9
-
Molecular Weight 775.93
-
Formel C41H57N7O8
-
Synonyms
MP-2
-
Sequence Shortening
LVVYPW
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Mikhailova AA, et al. Myelopeptide-2 recovers interleukin-2 synthesis and interleukin-2 receptor expression in human T lymphocytes depressed by tumor products or measles virus. J Immunother. 2006 May-Jun;29(3):306-12. [Content Brief]
[2]. Mikhailova AA, et al. Effect of myelopeptide-2 on the development of spontaneous and urethane-induced tumors in mice. Bull Exp Biol Med. 2002 Jan;133(1):68-70. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Myelopeptide-2 Related Classifications
HY-P3736 Related Classifications
Powered by Bioz