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Dizocilpine

(Synonyms: MK-801)
49 Cited Publications
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Based on 49 publication(s) in Google Scholar

Dizocilpine (MK-801), a potent anticonvulsant, is a selective and non-competitive NMDA receptor antagonist, with a Kd of 37.2 nM in rat brain membranes. Dizocilpine acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca2+ flux.

For research use only. We do not sell to patients.

  • Purity: 99.95%
  • CAS No.: 77086-21-6
  • Formula: C16H15N
  • Molecular Weight:221.30
  • Storage:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Dizocilpine Chemical Structure
    Dizocilpine Chemical Structure
  • Experimental Validation Results for Dizocilpine
  • Experimental Validation Results for Dizocilpine
  • Experimental Validation Results for Dizocilpine
  • Experimental Validation Results for Dizocilpine
  • Experimental Validation Results for Dizocilpine
  • Experimental Validation Results for Dizocilpine
  • Experimental Validation Results for Dizocilpine
  • Experimental Validation Results for Dizocilpine
CAS No.: 77086-21-6
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Cell Migration/Invasion AssayFlow CytometryIn Vivo Efficacy StudyHistological Imaging/StainingWB
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  • Dizocilpine Chemical Structure
    Dizocilpine Chemical Structure
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    Dizocilpine purchased from MedChemExpress. Usage Cited in: Sci Bull. 2025 Apr 15;70(7):1126-1138. [Abstract]

    Customer Validation
     The invasion assay was conducted using SUM159 cells (left) or 4T1 cells (right) treated with NAAG, MK801 (100 μM), or the combination.

  • 1/16

    Dizocilpine purchased from MedChemExpress. Usage Cited in: Sci Bull. 2025 Apr 15;70(7):1126-1138. [Abstract]

    Customer Validation
     BMCs were treated with NAAG, MK801 (100 μM), or the combination for 5 d. The PMN-MDSC percentages in BMCs were analyzed using flow cytometry.

  • 1/16

    Dizocilpine purchased from MedChemExpress. Usage Cited in: Sci Bull. 2025 Apr 15;70(7):1126-1138. [Abstract]

    Customer Validation
     BMCs were treated with NAAG, MK801 (100 μM), or the combination for 5 d. The cells were collected and lysed for Western blotting to detect ARG1 expression.

  • 1/16

    Dizocilpine purchased from MedChemExpress. Usage Cited in: Sci Bull. 2025 Apr 15;70(7):1126-1138. [Abstract]

    Customer Validation
     The tumor growth curve of 4T1 allograft mice treated with NAAG, MK801 (i.p., 1 mg/kg, 5 d a week), or the combination (n = 6).

  • 1/16

    Dizocilpine purchased from MedChemExpress. Usage Cited in: Sci Bull. 2025 Apr 15;70(7):1126-1138. [Abstract]

    Customer Validation
     HE staining of lungs from 4T1 tumor-bearing mice treated with NAAG, MK801 (i.p., 1 mg/kg, 5 d a week), or the combination. Representative images (left) and a bar graph (right) were shown. Scale bar, 200 μm.

  • 1/16

    Dizocilpine purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Mar 16;13(1):57. [Abstract]

    Customer Validation
     Dizocilpine (MK-801; 1 mg/kg; i.v.; single) suppresses RIPC-induced SIRT3 upregulation in mice.

  • 1/16

    Dizocilpine purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2020 Aug;24(16):9287-9299. [Abstract]

    Customer Validation
     Neurons are pre-treated with 10 μM Dizocilpine (MK801), followed by TNF-α treatment (40 ng/mL, 2 h). MK801 could attenuate TNF-α- induced intracellular calcium accumulation, phosphorylation of CAMK II and calpain-2, calpain activation and cathepsin B release as well as TrkB truncation.

  • 1/16

    Dizocilpine purchased from MedChemExpress. Usage Cited in: Neuroreport. 2017 May 24;28(8):444-450. [Abstract]

    Customer Validation
     Western blot analysis confirms that MK-801 inhibits the decrease in GDF10 in SNL rats. The relative expression level of GDF10 in the SNL-vehicle group is significantly decreased, but remains unchanged in the SNL-MK-801 group versus sham.

  • Dizocilpine