Podentamig
Based on 1 Customer Validation
Podentamig (HPN 217) is a trispecific construct with three binding domains, including an anti-CD3 domain for T cell activation, an anti-BCMA domain for binding to plasma cells, and an anti-albumin domain for half-life extension. Podentamig is applicable to research related to relapsed/refractory multiple myeloma.
For research use only. We do not sell to patients.
- Purity: 99.66%
- CAS No.: 2851863-52-8
- Molecular Weight:53.48 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
VH-VH'-(scFv-heavy-lambda)
Species Reactivity
Human
IC50 & Target
CD3E/TNFRSF17[1]
In Vitro
Podentamig has three binding domains, including an anti-CD3 domain for T cell activation, an anti-BCMA domain for binding to plasma cells, and an anti-albumin domain for half-life extension[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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VH-VH-scFvhl
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized CD3D-CD3E Heterodimer Protein, Human (HEK293, HY-P77610) can bind Podentamig, The ED50 for this effect is 17.29 ng/mL. -
Immobilized BCMA/TNFRSF17 Protein, Human (HEK293, HY-P70827) can bind Podentamig, The ED50 for this effect is 395.8 ng/mL.
Chemical Information
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CAS No. 2851863-52-8
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Appearance Liquid
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Molecular Weight 53.48 kDa
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Color Colorless to light yellow
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SMILES
[Podentamig]
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Synonyms
HPN 217
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)