Takeda-6D
Based on 1 Customer Validation
Takeda-6D (compound 6d) is an orally active and potent BRAF/VEGFR2 inhibitor, with IC50 values of 7.0 and 2.2 nM, respectively. Takeda-6D shows antiangiogenesis by suppressing the VEGFR2 pathway in 293/KDR and VEGF-stimulated HUVEC cells.Takeda-6D shows significant suppression of ERK1/2 phosphorylation. Takeda-6D shows antitumor activity.
For research use only. We do not sell to patients.
- Purity: 99.41%
- CAS No.: 1125632-93-0
- Formula: C27H19ClFN5O3S
- Molecular Weight:547.99
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All VEGFR Isoforms
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Biological Activity
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VEGFR2 2.2 nM (IC50) |
Braf 7.0 nM (IC50) |
Takeda-6D (0-10 mg/kg, Orally, once) significantly decreases phosphorylation levels of ERK1/24 h after oral administration in an A375 (BRAFV600E mutant) human melanoma xenograft model in rats[1].
Takeda-6D (10 mg/kg, Orally, twice daily for 2 weeks) shows tumor regression with T/Cof −7.0% without severe toxicity, and this tumor regression should include the efficacy based on the antiangiogenesis potency and BRAF inhibitory activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1125632-93-0
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Appearance Solid
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Molecular Weight 547.99
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Formula C27H19ClFN5O3S
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Color White to light yellow
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SMILES
O=C(NC1=CC(OC2=CC=C3C(SC(NC(C4CC4)=O)=N3)=N2)=CC=C1F)C5=CC=CC(C6(C#N)CC6)=C5Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (91.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8249 mL | 9.1243 mL | 18.2485 mL | 45.6213 mL |
| 5 mM | 0.3650 mL | 1.8249 mL | 3.6497 mL | 9.1243 mL | |
| 10 mM | 0.1825 mL | 0.9124 mL | 1.8249 mL | 4.5621 mL | |
| 15 mM | 0.1217 mL | 0.6083 mL | 1.2166 mL | 3.0414 mL | |
| 20 mM | 0.0912 mL | 0.4562 mL | 0.9124 mL | 2.2811 mL | |
| 25 mM | 0.0730 mL | 0.3650 mL | 0.7299 mL | 1.8249 mL | |
| 30 mM | 0.0608 mL | 0.3041 mL | 0.6083 mL | 1.5207 mL | |
| 40 mM | 0.0456 mL | 0.2281 mL | 0.4562 mL | 1.1405 mL | |
| 50 mM | 0.0365 mL | 0.1825 mL | 0.3650 mL | 0.9124 mL | |
| 60 mM | 0.0304 mL | 0.1521 mL | 0.3041 mL | 0.7604 mL | |
| 80 mM | 0.0228 mL | 0.1141 mL | 0.2281 mL | 0.5703 mL |
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