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Nintedanib

(Synonyms: BIBF 1120)
74 Cited Publications
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Based on 74 publication(s) in Google Scholar

Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

For research use only. We do not sell to patients.

  • Purity: 99.90%
  • CAS No.: 656247-17-5
  • Formula: C31H33N5O4
  • Molecular Weight:539.62
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Nintedanib Chemical Structure
    Nintedanib Chemical Structure
  • Experimental Validation Results for Nintedanib
  • Experimental Validation Results for Nintedanib
  • Experimental Validation Results for Nintedanib
  • Experimental Validation Results for Nintedanib
  • Experimental Validation Results for Nintedanib
  • Experimental Validation Results for Nintedanib
CAS No.: 656247-17-5
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Cell Imaging/StainingIn Vivo Efficacy StudyCell Proliferation/Viability AssayHistological Imaging/StainingWB
  • Cell Imaging/Staining
  • Cell Proliferation/Viability Assay
  • In Vivo Efficacy Study
  • Histological Imaging/Staining
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All PDGFR Isoforms

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All VEGFR Isoforms

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  • Nintedanib Chemical Structure
    Nintedanib Chemical Structure
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    Nintedanib purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2023 Nov 22:33:262-278. [Abstract]

    Customer Validation
     CLSM images of E-cadherin immunostaining in A549 cells after TGF-β (10 ng/mL) stimulation with Nintedanib (10 μM), PF (50 μM), n-PN (10 μM), and p-LP (50 μM) for 48 h were obtained.

  • 1/16

    Nintedanib purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2023 Nov 22:33:262-278. [Abstract]

    Customer Validation
     Cell growth inhibition of nintedanib (48 h), PF, n-PN, and p-LP at various concentrations in NIH/3T3 fibroblasts was assessed using an MTT assay.

  • 1/16

    Nintedanib purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2022 Sep 28;14(664):eabo5070. [Abstract]

    Customer Validation
     Nintedanib (60 mg/kg). Mice were dosed once daily by oral gavage with either 100 μL of the suspension, and animals were monitored for weight loss.

  • 1/16

    Nintedanib purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2022 Sep 28;14(664):eabo5070. [Abstract]

    Customer Validation
     Nintedanib (60 mg/kg). Mice were dosed once daily by oral gavage with either 100 μL of the suspension, and histopathological analysis of lungs was performed.

  • 1/16

    Nintedanib purchased from MedChemExpress. Usage Cited in: Sci Rep. 2018 Jun 22;8(1):9540. [Abstract]

    Customer Validation
     Western blot based detection of cell cycle associated molecules viz., Cyclins A, D1 and E, and CDKs 2, 4 and 6 in PC3, and LNCaP cells after 72 hours of Nintedanib treatment.

  • 1/16

    Nintedanib purchased from MedChemExpress. Usage Cited in: Oncol Rep. 2016 Dec;36(6):3123-3130. [Abstract]

    Customer Validation
     The mice are treated with TFTD alone (150 mg/kg, orally twice daily from days 1 to 14, open column), or a combination of TFTD and Nintedanib (closed column). The HT-29 and HCT116 tumors are collected at 24 h following the final administration of the drugs (day 15). The values indicate the mean ± SD (n=6).

  • Nintedanib