Fazpilodemab
Based on 1 Customer Validation
Fazpilodemab (BFKB8488A) is a humanized bispecific IgG1 antibody that selectively targets and activates fibroblast growth factor receptor 1c (FGFR1c) and Klothoβ. Fazpilodemab can be used for the research of type 2 diabetes mellitus (T2DM) or nonalcoholic fatty liver disease (NAFLD).
For research use only. We do not sell to patients.
- Purity: 99.99%
- CAS No.: 2517935-02-1
- Molecular Weight:144.48 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG1 kappa
Human
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FGFR1c |
Klothoβ |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male, insulin-independent, drug-naive, obese cynomolgus monkeys (aged 12 to 16 years; body weight, 8.5 to 14.6 kg)[2].
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Dosage:0.6 mg/kg, 3 mg/kg, or 15 mg/kg
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Administration:Intravenous injection; single dose
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Result:Activateed the receptor complex, increased serum adiponectin, and decreased body weight and food intake in obese nonhuman primates.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Flow cytometric analysis of 1X106 HepG2 cells labeling KLB with Fazpilodemab (HY-P99614, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.
Chemical Information
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CAS No. 2517935-02-1
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Appearance Liquid
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Molecular Weight 144.48 kDa
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Color Colorless to light yellow
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SMILES
[Fazpilodemab]
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Synonyms
BFKB8488A; RG-7992; RO-7040551
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Wong C, et al. Fibroblast growth factor receptor 1/Klothoβ agonist BFKB8488A improves lipids and liver health markers in patients with diabetes or NAFLD: A phase 1b randomized trial. Hepatology. 2022 Aug 22. [Content Brief]
[2]. Baruch A, et al. Antibody-mediated activation of the FGFR1/Klothoβ complex corrects metabolic dysfunction and alters food preference in obese humans. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):28992-29000. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)