Lecithin
Based on 8 publication(s) in Google Scholar
Lecithin is regarded as a safe, conventional phospholipid source. Phospholipids are reported to alter the fatty acid composition and microstructure of the membranes in animal cells.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 8002-43-5
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Protocol
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Lecithin
More- Bioact Mater. 2025 Nov 14:57:305-322. [Abstract]
- Nat Microbiol. 2025 Nov;10(11):2949-2965. [Abstract]
- Autophagy. 2025 Jul 6:1-20. [Abstract]
- Adv Sci (Weinh). 2025 Nov 14:e17330. [Abstract]
- Adv Sci (Weinh). 2024 Mar;11(12):e2307870. [Abstract]
- Biomater Res. 2022 Sep 22;26(1):47. [Abstract]
- J Funct Foods. 2024 Feb, 113, 106041.
- Authorea. 2023 Jul 18.
Customer Validation & Images
-
Cell Proliferation/Viability Assay
-
In Vivo Efficacy Study
-
In Vivo Efficacy Study
All Endogenous Metabolite Isoforms
More
Biological Activity
|
Microbial Metabolite |
Human Endogenous Metabolite |
After culturing in MRS broth with 0.2 to 1.0% soy Lecithin, the survival rate of harvested cells increases significantly (P<0.05) in the 0.3% bile challenge compare with the no added soy Lecithin group. The cells incubated with 0.6% soy Lecithin are able to grow in an MRS broth with a higher bile salt content. The cell surface hydrophobicity is enhanced and the membrane integrity in the bile challenge increases after culturing with soy Lecithin. A shift in the fatty acid composition is also observed, illustrating the cell membrane changes in the soy Lecithin culture[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 8002-43-5
-
Appearance Solid
-
Color Light brown to yellow
-
SMILES
O=P(OCC[N+](C)(C)C)([O-])OC[C@@H](COC([R])=O)OC([R'])=O.[R,R'=fatty acid residues]
-
Synonyms
Polyene phosphatidylcholine
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (8)
-
Journal Impact Factor
-
Most Recent
-
Bioact Mater
Cell-penetrating peptide-functionalized biomimetic nanovesicles for efficient cataract treatment via enhanced corneal penetration and lens-mitochondria dual targeting. [Abstract]2025 Nov 14:57:305-322. PMID: 41323208 -
Nat Microbiol
Mycobacterium tuberculosis-derived linoleic acid increases regulatory T cell function to promote bacterial survival within macrophages. [Abstract]2025 Nov;10(11):2949-2965. PMID: 41073667 -
Autophagy
2025 Jul 6:1-20. PMID: 40568844 -
Adv Sci (Weinh)
Obesity-Associated TRIM15 Promotes the Proliferation of Esophageal Adenocarcinoma Through the YY2/FOXRED1 Axis. [Abstract]2025 Nov 14:e17330. PMID: 41237333
Lecithin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 14:e17330. [Abstract]
Addition of GPLs (PCs, PEs, LysoPCs, and LysoPAs; each at 10 µg/mL) to EAC cells for 5 days attenuated the inhibitory effect of TRIM15 knockdown or FOXRED1 overexpression on cell proliferation.
-
Adv Sci (Weinh)
Enhanced Photodynamic Therapy Synergizing with Inhibition of Tumor Neutrophil Ferroptosis Boosts Anti-PD-1 Therapy of Gastric Cancer. [Abstract]2024 Mar;11(12):e2307870. PMID: 38233204 -
Biomater Res
Oxygen tank for synergistic hypoxia relief to enhance mitochondria-targeted photodynamic therapy. [Abstract]2022 Sep 22;26(1):47. PMID: 36138489 -
Lecithin purchased from MedChemExpress. Usage Cited in: J Funct Foods. 2024 Feb, 113, 106041.
We measured the body weight of mice weekly and the food intake daily for each group. Compared with the control group, the body weight in NAFLD group was obviously increased after 8 and 10 weeks of HFD. However, after 4 weeks of treatment with Eri, the body weight of mice in the Eri-L and Eri-H groups exhibited a significant reduction; however, no notable decrease was observed in the Lecithin (PPC, 150 mg/kg, oral, daily) group. After 6 weeks of Lecithin and Eri treatment, the body weight of mice in the Lecithin, Eri-L, and Eri-H groups was significantly lower than that of mice in the NAFLD group.
Lecithin purchased from MedChemExpress. Usage Cited in: J Funct Foods. 2024 Feb, 113, 106041.
Compared with that in the NAFLD group, after 4 or 6 weeks of Eri intervention, the food intake in the Lecithin (PPC, 150 mg/kg, oral, daily), Eri-L and Eri-H groups was significantly decreased.
-
Solvent & Solubility
Ethanol : < 1 mg/mL (insoluble)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 0.5 mg/mL; Clear solution
This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 0.5 mg/mL; Clear solution
This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Protocol
MRS broths are supplemented with soy Lecithin concentrations of 0, 0.2, 0.4, 0.6, 0.8 and 1.0%. Each broth is inoculated with a tested strain culture (2%, v/v) and anaerobically incubated at 37°C for 20 h. After incubation, the bacterium cells are harvested by centrifugation at 8000 g for 10 min at 4°C and washed twice in PBS (pH 6.5) plus ethanol (5%, v/v). Strain bile resistance is assessed. The numbers of viable cells are counted by the pouring plate method, and each batch is tested three times[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
-
Data Sheet (275 KB)
-
SDS (647 KB)
- English - EN (647 KB)
- Français - FR (647 KB)
- Deutsch - DE (647 KB)
- Norwegian - NO (647 KB)
- Español - ES (647 KB)
- Swedish - SV (647 KB)
- Italian - IT (647 KB)
- Portuguese - PT (647 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz