BNIP2 - BCL2 interacting protein 2 Gene

Also Known as NIP2; BNIP-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 663

About BNIP2

Cytogenetic location: 15q22.2 Genomic coordinates (GRCh38): 15:59,659,146-59,689,320 (from NCBI)

This gene has 11 transcripts (splice variants), 197 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 22.4), fat (RPKM 13.5) and 24 other tissues.

Summary

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

BNIP2 Products (8)

mRNA Protein Name
NM_001320674.2 NP_001307603.2 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 1
NM_001320675.4 NP_001307604.2 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 2
NM_001368057.1 NP_001354986.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 4
NM_001368058.1 NP_001354987.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 5
NM_001368059.1 NP_001354988.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 6
NM_001368060.1 NP_001354989.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 7
NM_001368061.1 NP_001354990.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 8
NM_004330.4 NP_004321.3 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
7954800 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
7954800 GOA
located in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
7954800 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
7954800 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BNIP2 Protein Structure

BNIP2

BNIP2: Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 (48 - 163)

CRAL_TRIO_2

CRAL_TRIO_2: Divergent CRAL/TRIO domain (165 - 287)

  • 0
  • 100
  • 200
  • 300
  • 314 a.a.
Protein Preferred Names Protein Names

BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

  • BCL2/adenovirus E1B 19kDa interacting protein 2

BNIP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BNIP2 Q12982 LDLRAD1 Homo sapiens Q5T700
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 LDLRAD1 Homo sapiens Q5T700
Validated Y2H
32296183
Intra
BNIP2 Q12982 LDLRAD1 Homo sapiens Q5T700
Y2H Array
32296183
Intra
BNIP2 Q12982 b2r9h7_human Homo sapiens B2R9H7
Y2H Array
25416956
Intra
BNIP2 Q12982 CYB5R3 Homo sapiens P00387
Y2H Array
32296183
Intra
BNIP2 Q12982 CYB5R3 Homo sapiens P00387
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
Intra
BNIP2 Q12982 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
BNIP2 Q12982 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
BNIP2 Q12982 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
BNIP2 Q12982 GRAMD2A Homo sapiens Q8IUY3
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 GRAMD2A Homo sapiens Q8IUY3
Validated Y2H
32296183
Intra
BNIP2 Q12982 GRAMD2A Homo sapiens Q8IUY3
Y2H Array
32296183
Intra
BNIP2 Q12982 TMPRSS2 Homo sapiens O15393-2
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 TMPRSS2 Homo sapiens O15393-2
Y2H Array
32296183
Intra
BNIP2 Q12982 BNIP5 Homo sapiens P0C671
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 BNIP5 Homo sapiens P0C671
Y2H Array
32296183
Intra
BNIP2 Q12982 RASGRP4 Homo sapiens Q8TDF6-2
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 RASGRP4 Homo sapiens Q8TDF6-2
Validated Y2H
32296183
Intra
BNIP2 Q12982 RASGRP4 Homo sapiens Q8TDF6-2
Y2H Array
32296183
Intra
BNIP2 Q12982 DGAT2L6 Homo sapiens Q6ZPD8
Y2H Array
32296183
Intra
BNIP2 Q12982 DGAT2L6 Homo sapiens Q6ZPD8
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 DGAT2L6 Homo sapiens Q6ZPD8
Validated Y2H
32296183
Intra
BNIP2 Q12982 DESI2 Homo sapiens Q9BSY9
Validated Y2H
32296183
Intra
BNIP2 Q12982 DESI2 Homo sapiens Q9BSY9
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 DESI2 Homo sapiens Q9BSY9
Y2H Array
32296183
Intra
BNIP2 Q12982 FAHD1 Homo sapiens Q6P587-2
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 FAHD1 Homo sapiens Q6P587-2
Y2H Array
32296183
Intra
BNIP2 Q12982 FAHD1 Homo sapiens Q6P587-2
Validated Y2H
32296183
Intra
BNIP2 Q12982 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
BNIP2 Q12982 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
BNIP2 Q12982 SIN3A Homo sapiens H3BQL7
Y2H Array
32296183
Intra
BNIP2 Q12982 SIN3A Homo sapiens H3BQL7
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 SLC35E3 Homo sapiens Q7Z769
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 SLC35E3 Homo sapiens Q7Z769
Validated Y2H
32296183
Intra
BNIP2 Q12982 SLC35E3 Homo sapiens Q7Z769
Y2H Array
32296183
Intra
BNIP2 Q12982 FRK Homo sapiens P42685
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 FRK Homo sapiens P42685
Y2H Array
25416956
Intra
BNIP2 Q12982 FRK Homo sapiens P42685
Y2H Array
32296183
Intra
BNIP2 Q12982 FRK Homo sapiens P42685
Y2H Array
31515488
Intra
BNIP2 Q12982 MYO5B Homo sapiens Q9ULV0-2
Validated Y2H
32296183
Intra
BNIP2 Q12982 MYO5B Homo sapiens Q9ULV0-2
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 MYO5B Homo sapiens Q9ULV0-2
Y2H Array
32296183
Intra
BNIP2 Q12982 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
BNIP2 Q12982 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
BNIP2 Q12982 CHODL Homo sapiens Q9H9P2
Y2H Array
32296183
Intra
BNIP2 Q12982 CHODL Homo sapiens Q9H9P2
Validated Y2H
32296183
Intra
BNIP2 Q12982 CHODL Homo sapiens Q9H9P2
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 APOBEC3B Homo sapiens Q9UH17-2
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 APOBEC3B Homo sapiens Q9UH17-2
Y2H Array
32296183
Intra
BNIP2 Q12982 APOBEC3B Homo sapiens Q9UH17-2
Validated Y2H
32296183
Intra
BNIP2 Q12982 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra
BNIP2 Q12982 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
BNIP2 Q12982 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
BNIP2 Q12982 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
BNIP2 Q12982 GSC2 Homo sapiens O15499
Y2H Array
32296183
Intra
BNIP2 Q12982 GSC2 Homo sapiens O15499
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 EI24 Homo sapiens O14681
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 EI24 Homo sapiens O14681
Y2H Array
32296183
Intra
BNIP2 Q12982 YIF1A Homo sapiens O95070
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 YIF1A Homo sapiens O95070
Y2H Array
32296183
Intra
BNIP2 Q12982 AGPAT3 Homo sapiens Q9NRZ7
Validated Y2H
32296183
Intra
BNIP2 Q12982 AGPAT3 Homo sapiens Q9NRZ7
Y2H Array
32296183
Intra
BNIP2 Q12982 AGPAT3 Homo sapiens Q9NRZ7
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 SLC39A9 Homo sapiens Q9NUM3
Y2H Array
32296183
Intra
BNIP2 Q12982 SLC39A9 Homo sapiens Q9NUM3
Validated Y2H
32296183
Intra
BNIP2 Q12982 SLC39A9 Homo sapiens Q9NUM3
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 LIME1 Homo sapiens Q9H400
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 LIME1 Homo sapiens Q9H400
Y2H Array
32296183
Intra
BNIP2 Q12982 LIME1 Homo sapiens Q9H400
Validated Y2H
32296183
Intra
BNIP2 Q12982 MEOX1 Homo sapiens P50221
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 MEOX1 Homo sapiens P50221
Y2H Array
32296183
Intra
BNIP2 Q12982 FAM3C Homo sapiens Q92520
Validated Y2H
32296183
Intra
BNIP2 Q12982 MYO5B Homo sapiens Q9ULV0
Validated Y2H
25416956
Intra
BNIP2 Q12982 MYO5B Homo sapiens Q9ULV0
Y2H Array
25416956
Intra
BNIP2 Q12982 MYO5B Homo sapiens Q9ULV0
Y2H Prey Pooling
25416956
Intra
BNIP2 Q12982 ERLIN1 Homo sapiens O75477
Y2H Array
32296183
Intra
BNIP2 Q12982 ERLIN1 Homo sapiens O75477
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 GORAB Homo sapiens Q5T7V8
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 GORAB Homo sapiens Q5T7V8
Validated Y2H
32296183
Intra
BNIP2 Q12982 GORAB Homo sapiens Q5T7V8
Y2H Array
32296183
Intra
BNIP2 Q12982 KCNK5 Homo sapiens O95279
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 KCNK5 Homo sapiens O95279
Y2H Array
32296183
Intra
BNIP2 Q12982 SFT2D2 Homo sapiens O95562
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 SFT2D2 Homo sapiens O95562
Y2H Array
32296183
Intra
BNIP2 Q12982 SLC7A14 Homo sapiens Q8TBB6
Y2H Array
32296183
Intra
BNIP2 Q12982 SLC7A14 Homo sapiens Q8TBB6
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 SLC7A14 Homo sapiens Q8TBB6
Validated Y2H
32296183
Intra
BNIP2 Q12982 SYT1 Homo sapiens P21579
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 SYT1 Homo sapiens P21579
Y2H Array
32296183
Intra
BNIP2 Q12982 PEX12 Homo sapiens O00623
Y2H Array
32296183
Intra
BNIP2 Q12982 PEX12 Homo sapiens O00623
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
BNIP2 Q12982 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
BNIP2 Q12982 ABHD4 Homo sapiens Q8TB40
Y2H Array
32296183
Intra
BNIP2 Q12982 ABHD4 Homo sapiens Q8TB40
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 ABHD4 Homo sapiens Q8TB40
Validated Y2H
32296183
Intra
BNIP2 Q12982 KLC1 Homo sapiens Q07866
Y2H Prey Pooling
25416956
Intra
BNIP2 Q12982 KLC1 Homo sapiens Q07866
Y2H Array
25416956
Intra
BNIP2 Q12982 FATE1 Homo sapiens Q969F0
Y2H Array
32296183
Intra
BNIP2 Q12982 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 DHRS1 Homo sapiens Q96LJ7
Y2H Array
32296183
Intra
BNIP2 Q12982 DHRS1 Homo sapiens Q96LJ7
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 DHRS1 Homo sapiens Q96LJ7
Validated Y2H
32296183
Intra
BNIP2 Q12982 BNIP3 Homo sapiens Q12983
Y2H Array
32296183
Intra
BNIP2 Q12982 BNIP3 Homo sapiens Q12983
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 BNIP3 Homo sapiens Q12983
Validated Y2H
32296183
Intra
BNIP2 Q12982 SYT2 Homo sapiens Q8N9I0
Validated Y2H
32296183
Intra
BNIP2 Q12982 SYT2 Homo sapiens Q8N9I0
Y2H Array
32296183
Intra
BNIP2 Q12982 SYT2 Homo sapiens Q8N9I0
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 OTX2 Homo sapiens P32243-2
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 OTX2 Homo sapiens P32243-2
Y2H Array
32296183
Intra
BNIP2 Q12982 PLEKHO1 Homo sapiens Q53GL0
Y2H Array
32296183
Intra
BNIP2 Q12982 PLEKHO1 Homo sapiens Q53GL0
Y2H Prey Pooling
32296183
Intra
BNIP2 Q12982 PLEKHO1 Homo sapiens Q53GL0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

BNIP2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810083 BNIP-2 Antibody (YA9427) WB, ICC/IF, IF-Tissue, IP, ELISA human
HY-P810852 BNIP2 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Cerebellar Ataxia, Cayman Type

  • Cayman Type Cerebellar Ataxia

  • Ataxia, Cerebellar, Cayman Type

  • ATCAY

  • Cayman Cerebellar Ataxia

  • Cayman Ataxia
Nephronophthisis 3

  • NPHP3

  • Nph3

  • Adolescent Nephronophthisis

  • Nephronophthisis, Type 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01563 BNIP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus BNIP2 MGD MGI:109327
Macaca mulatta BNIP2 VGNC VGNC:70272
Bos taurus BNIP2 VGNC VGNC:26532
Rattus norvegicus BNIP2 RGD RGD:1308944
Felis catus BNIP2 VGNC VGNC:60144
Canis familiaris BNIP2 VGNC VGNC:58293
Others BNIP2 NCBI