10-Hydroxywarfarin
Based on 1 Customer Validation
10-Hydroxywarfarin, a metabolite of (R)-(+)-Warfarin (HY-W015998 ), is a CYP2C9 and vitamin K epoxide reductase complex 1 (VKOR) inhibitor with IC50s of 1.6 µM and 80 ng/mL, respectively.
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- No. CAS: 83219-99-2
- Fòrmula: C19H16O5
- Peso molecular:324.33
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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CYP2C9 1.6 μM (IC50) |
VKOR 80 ng/mL (IC50) |
Chemical Information
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No. CAS 83219-99-2
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Appearance Solid
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Peso molecular 324.33
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Fòrmula C19H16O5
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SMILES
O=C1C(C(C2=CC=CC=C2)C(O)C(C)=O)=C(O)C3=CC=CC=C3O1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Shuhei Kobayashi, et al. Combination index of the concentration and in vivo antagonism activity of racemic warfarin and its metabolites to assess individual drug responses. J Thromb Thrombolysis. 2019 Apr;47(3):467-472. [Content Brief]
[2]. Drew R Jones, et al. Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin. Chem Res Toxicol. 2010 May 17;23(5):939-45. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
10-Hydroxywarfarin Related Classifications
HY-134999 Related Classifications
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