ddTTP trisodium solution (100 mM)
Based on 1 Customer Validation
ddTTP trisodium solution (100 mM) is a DNA polymerase γ inhibitor, with Ki values of 0.05 μM and 0.4 μM against bovine testicular DNA polymerase γ. ddTTP trisodium solution (100 mM) can be incorporated into DNA to cause termination of the extended DNA strand. ddTTP trisodium solution (100 mM) can be used in the research of HIV infection.
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- Pureza: 99.91%
- Fòrmula: C10H14N2Na3O13P3
- Peso molecular:532.11
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Almacenamiento:
Solution, -20°C, 2 years
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Actividad biológica
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Chemical Information
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Actividad biológica
ddTTP trisodium solution (100 mM) (0-100 μM; 30 min) potently inhibits bovine testicular DNA polymerase γ in a competitive manner relative to dTTP, with a Ki value of 0.05 μM when poly (rA)-oligo (dT) serves as the template-primer[1].
trisodium solution (100 mM) ddTTP (0-100 μM; 30 min) potently inhibits bovine testicular DNA polymerase γ in a competitive manner relative to dTTP, with a Ki value of 0.4 μM when activated calf thymus DNA is used as the template-primer[1].
trisodium solution (100 mM) ddTTP (2.5-10 μM; 60 min) can be incorporated into DNA by bovine testicular DNA polymerase γ and induce chain termination, and this effect is independent of 3'-exonuclease proofreading activity (verified by treatment with 1 mM 5'-GMP)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Liquid
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Peso molecular 532.11
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Fòrmula C10H14N2Na3O13P3
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Color Colorless to light yellow
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SMILES
O=[P](O[P](O[P](O)(O[Na])=O)(O[Na])=O)(O[Na])OC[C@@H](O1)CC[C@@H]1N(C(NC2=O)=O)C=C2C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Solution, -20°C, 2 years
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ddTTP trisodium solution (100 mM) Related Classifications
HY-137694B Related Classifications
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