Estrone-d2-1
Based on 1 Customer Validation
Estrone-d2-1 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells.
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- Pureza: 95.0%
- No. CAS: 56588-58-0
- Fòrmula: C18H20D2O2
- Peso molecular:272.38
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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No. CAS 56588-58-0
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Unlabeled Cas 53-16-7
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Appearance Solid
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Peso molecular 272.38
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Fòrmula C18H20D2O2
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Color White to off-white
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SMILES
C[C@]1([C@](CC2([2H])[2H])([H])[C@]3([H])CCC4=C(C=CC(O)=C4)[C@@]3([H])CC1)C2=O
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Synonyms
E1-d2-1; Oestrone-d2-1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 25 mg/mL (91.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Caupos E, et al. Photodegradation of estrone enhanced by dissolved organic matter under simulated sunlight. Water Res. 2011;45(11):3341-3350. [Content Brief]
[3]. de Padua Mansur A, et al. Long-term prospective study of the influence of estrone levels on events in postmenopausal women with or at high risk for coronary artery disease. ScientificWorldJournal. 2012;2012:363595. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6713 mL | 18.3567 mL | 36.7134 mL | 91.7835 mL |
| 5 mM | 0.7343 mL | 3.6713 mL | 7.3427 mL | 18.3567 mL | |
| 10 mM | 0.3671 mL | 1.8357 mL | 3.6713 mL | 9.1784 mL | |
| 15 mM | 0.2448 mL | 1.2238 mL | 2.4476 mL | 6.1189 mL | |
| 20 mM | 0.1836 mL | 0.9178 mL | 1.8357 mL | 4.5892 mL | |
| 25 mM | 0.1469 mL | 0.7343 mL | 1.4685 mL | 3.6713 mL | |
| 30 mM | 0.1224 mL | 0.6119 mL | 1.2238 mL | 3.0595 mL | |
| 40 mM | 0.0918 mL | 0.4589 mL | 0.9178 mL | 2.2946 mL | |
| 50 mM | 0.0734 mL | 0.3671 mL | 0.7343 mL | 1.8357 mL | |
| 60 mM | 0.0612 mL | 0.3059 mL | 0.6119 mL | 1.5297 mL | |
| 80 mM | 0.0459 mL | 0.2295 mL | 0.4589 mL | 1.1473 mL |
Estrone-d2-1 Related Classifications
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