1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. FAUC 213

FAUC 213 

Cat. No.: HY-14327
Handling Instructions

FAUC 213 is an orally active and highly selective dopamine D4 receptor complete antagonist with a Ki of 2.2 nM for hD4.4. FAUC 213 has less activity on D2 and D3 receptors (Kis of 3.4 μM, 5.3 μM for hD2, hD3, respectively). FAUC 213 can cross the blood-brain barrier (BBB). FAUC 213 exhibits atypical antipsychotic characteristic.

For research use only. We do not sell to patients.

FAUC 213 Chemical Structure

FAUC 213 Chemical Structure

CAS No. : 337972-47-1

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Description

FAUC 213 is an orally active and highly selective dopamine D4 receptor complete antagonist with a Ki of 2.2 nM for hD4.4. FAUC 213 has less activity on D2 and D3 receptors (Kis of 3.4 μM, 5.3 μM for hD2, hD3, respectively). FAUC 213 can cross the blood-brain barrier (BBB). FAUC 213 exhibits atypical antipsychotic characteristic[1].

IC50 & Target[1]

hD4.4 Receptor

2.2 nM (Ki)

hD2 Receptor

3.4 μM (Ki)

hD3 Receptor

5.3 μM (Ki)

In Vitro

FAUC 213 inhibits p5-HT1 (Ki=1.2 μM),p5-HT2 (Ki=0.52 μM),pα1 (Ki=0.27 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

FAUC 213 (7.5-30 mg/kg; orally; single dose) significantly reduces this elevation in AMPH-induced locomotor hyper-activity only pre-treatment with 30 mg/kg. FAUC 213 significantly restores the prepulse inhibition (PPI) reduction caused by the apomorphine (APO) treatment with 30 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male adult Wistar rats weighing 300-350 g[1]
Dosage: 7.5, 15, 30 mg/kg
Administration: Orally; single dose
Result: Significantly reduced this elevation in amphetamin (AMPH)-induced locomotor hyper-activity only pre-treatment with 30 mg/kg.
Molecular Weight

326.82

Formula

C₁₈H₁₉ClN₄

CAS No.
SMILES

ClC(C=C1)=CC=C1N(CC2)CCN2CC3=NN4C=CC=CC4=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

FAUC 213FAUC213FAUC-213Dopamine Receptororallyblood-brainbarrierBBBantipsychoticp5-HT1p5-HT2pα1amphetaminAMPHInhibitorinhibitorinhibit

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FAUC 213
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HY-14327
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