MJ-26
MJ-26 is an inhibitor targeting Menin. MJ-26 has high binding affinity (Ki: 0.56 μM) and significant antiproliferative activity. MJ-26 works by inhibiting Menin-MLL interaction and inducing Menin protein degradation. MJ-26 has significant antitumor effects on acute myeloid leukemia (AML). MJ-26 can be used in AML research.
For research use only. We do not sell to patients.
- Formula: C38H47N9O4S2
- Molecular Weight:757.97
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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Molecular Weight 757.97
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Formula C38H47N9O4S2
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SMILES
CC1=C(N=C(S1)N2CC=C(CC2)C3=CC4=C(N=CN=C4N3)N5CCC(O)(CC5)C)C6=CC=CC(S(=O)(N7C[C@@H]8C[C@H]7CN8C(/C=C/CN(C)C)=O)=O)=C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
DMSO : 100 mg/mL (131.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.30 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.30 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3193 mL | 6.5966 mL | 13.1931 mL | 32.9828 mL |
| 5 mM | 0.2639 mL | 1.3193 mL | 2.6386 mL | 6.5966 mL | |
| 10 mM | 0.1319 mL | 0.6597 mL | 1.3193 mL | 3.2983 mL | |
| 15 mM | 0.0880 mL | 0.4398 mL | 0.8795 mL | 2.1989 mL | |
| 20 mM | 0.0660 mL | 0.3298 mL | 0.6597 mL | 1.6491 mL | |
| 25 mM | 0.0528 mL | 0.2639 mL | 0.5277 mL | 1.3193 mL | |
| 30 mM | 0.0440 mL | 0.2199 mL | 0.4398 mL | 1.0994 mL | |
| 40 mM | 0.0330 mL | 0.1649 mL | 0.3298 mL | 0.8246 mL | |
| 50 mM | 0.0264 mL | 0.1319 mL | 0.2639 mL | 0.6597 mL | |
| 60 mM | 0.0220 mL | 0.1099 mL | 0.2199 mL | 0.5497 mL | |
| 80 mM | 0.0165 mL | 0.0825 mL | 0.1649 mL | 0.4123 mL | |
| 100 mM | 0.0132 mL | 0.0660 mL | 0.1319 mL | 0.3298 mL |
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