BPH-1218
BPH-1218 is an inhibitor of squalene synthase (SQS), with the IC50 of 31 nM and 64 nM for TcSQS and HsSQS, respectively, that can be used as an anti-infective agent.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 1426824-36-3
- Formule: C15H30N2O6P2
- Masse moléculaire:396.36
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform Parasite
More
Activité biologique
0.17±0.04 μM (TgFPPS), 0.04±0.01 μM (TgCoq1)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| T-cell | IC50 |
11 μM
Compound: 27
|
Activation of human CD4+ Vgamma2/Vdelta2 T cell clone JN.23 assessed as TNF-alpha release after 16 hrs by sandwich ELISA in presence of antigen presenting cell line, CP.EBV
Activation of human CD4+ Vgamma2/Vdelta2 T cell clone JN.23 assessed as TNF-alpha release after 16 hrs by sandwich ELISA in presence of antigen presenting cell line, CP.EBV
|
[PMID: 23610597] |
Chemical Information
-
CAS No. 1426824-36-3
-
Masse moléculaire 396.36
-
Formule C15H30N2O6P2
-
SMILES
O=P(O)(C(P(O)(O)=O)C[N+]1=CN(CCCCCCCCCC)C=C1)[O-]
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Melissa A Sleda, wt al. The Heptaprenyl Diphosphate Synthase (Coq1) Is the Target of a Lipophilic Bisphosphonate That Protects Mice against Toxoplasma gondii Infection. mBio. 2022 Oct 26;13(5):e0196622. [Content Brief]
[2]. M J Barry, et al. Benign Prostatic Hyperplasia Specific Health Status Measures in Clinical Research: How Much Change in the American Urological Association Symptom Index and the Benign Prostatic Hyperplasia Impact Index is Perceptible to Patients? J Urol. 1995 Nov;154(5):1770-4. [Content Brief]
[3]. Na Shang, et al. Squalene Synthase As a Target for Chagas Disease Therapeutics. PLoS Pathog. 2014 May 1;10(5):e1004114. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BPH-1218 Related Classifications
HY-135625 Related Classifications
Powered by Bioz