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Cat. No.: HY-171468

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CC-1069

CC-1069, a structural analog of thalidomide (HY-14658), is a TNF-α inhibitor that inhibits endothelial. CC-1069 can be used to study angiogenesis-dependent tumors such as gliomas.

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CAS No.: 167887-03-8
Formule: C₁₉H₁₈N₂O₅
Masse moléculaire:354.36

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

CC-1069 Chemical Structure

CAS No.: 167887-03-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

CC-1069, a structural analog of thalidomide (HY-14658), is a TNF-α inhibitor that inhibits endothelial. CC-1069 can be used to study angiogenesis-dependent tumors such as gliomas^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
PBMC	IC₅₀	13 μM Compound: 3a	Inhibition of LPS stimulated Tumor Necrosis Factor-alpha (TNF-alpha) release by human PBMC Inhibition of LPS stimulated Tumor Necrosis Factor-alpha (TNF-alpha) release by human PBMC	[PMID: 9873600]
U-937	IC₅₀	9.4 μM Compound: 3a	Inhibition of PDE4 enzyme from U937 cells Inhibition of PDE4 enzyme from U937 cells	[PMID: 9873600]

Chemical Information

CAS No. 167887-03-8
Masse moléculaire 354.36
Formule C₁₉H₁₈N₂O₅
SMILES

O=C(CC(N1C(C2=C(C1=O)C=CC=C2)=O)C3=CC=C(C(OC)=C3)OC)N
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Moreira AL, et al. Thalidomide and a thalidomide analogue inhibit endothelial cell proliferation in vitro. J Neurooncol. 1999 Jun;43(2):109-14. [Content Brief]

Calculators

Calculateur de molarité

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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CC-1069

Voir tous les produits spécifiques à Isoform TNF Receptor