8-Bromoadenosine
Based on 1 Customer Validation
8-Bromoadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. 8-Bromoadenosine can quench the intrinsic fluorescence of human serum albumin (HSA) through static quenching procedure. 8-Bromoadenosine can be used to synthesize adenosine phosphate, such as Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
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- Pureza: 99.68%
- No. CAS: 2946-39-6
- Fòrmula: C10H12BrN5O4
- Peso molecular:346.14
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
8-Bromoadenosine reduces the fluorescence emission intensity of HSA[2].
8-Bromoadenosine binds to HSA with less stability as the temperature increases but the effect of temperature is very small[2].
8-Bromoadenosine has a decreased binding constants with HSA in the presence of other ions[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2946-39-6
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Appearance Solid
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Peso molecular 346.14
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Fòrmula C10H12BrN5O4
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C(Br)=NC3=C2N=CN=C3N)O[C@@H]1CO
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvente y solubilidad
DMSO : 100 mg/mL (288.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500. [Content Brief]
[2]. Cui, F., (2009). Characterization of the interaction between 8-bromoadenosine with human serum albumin and its analytical application. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 74(4), 964–971. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8890 mL | 14.4450 mL | 28.8900 mL | 72.2251 mL |
| 5 mM | 0.5778 mL | 2.8890 mL | 5.7780 mL | 14.4450 mL | |
| 10 mM | 0.2889 mL | 1.4445 mL | 2.8890 mL | 7.2225 mL | |
| 15 mM | 0.1926 mL | 0.9630 mL | 1.9260 mL | 4.8150 mL | |
| 20 mM | 0.1445 mL | 0.7223 mL | 1.4445 mL | 3.6113 mL | |
| 25 mM | 0.1156 mL | 0.5778 mL | 1.1556 mL | 2.8890 mL | |
| 30 mM | 0.0963 mL | 0.4815 mL | 0.9630 mL | 2.4075 mL | |
| 40 mM | 0.0722 mL | 0.3611 mL | 0.7223 mL | 1.8056 mL | |
| 50 mM | 0.0578 mL | 0.2889 mL | 0.5778 mL | 1.4445 mL | |
| 60 mM | 0.0482 mL | 0.2408 mL | 0.4815 mL | 1.2038 mL | |
| 80 mM | 0.0361 mL | 0.1806 mL | 0.3611 mL | 0.9028 mL | |
| 100 mM | 0.0289 mL | 0.1445 mL | 0.2889 mL | 0.7223 mL |
8-Bromoadenosine Related Classifications
HY-W013195 Related Classifications
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