Referencia número: HY-16059

Arglabin

(Synonyms: (+)-Arglabin)

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Based on 1 Customer Validation

Arglabin ((+)-Arglabin), a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor. Arglabin shows anti-inflammatory and antitumor activities. The antitumor activity of Arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene.

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Pureza: 99.87%
No. CAS: 84692-91-1
Fòrmula: C₁₅H₁₈O₃
Peso molecular:246.31

Almacenamiento:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Arglabin Chemical Structure

No. CAS: 84692-91-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Solvente y solubilidad
- In Vitro
- In Vivo
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Arglabin ((+)-Arglabin), a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor. Arglabin shows anti-inflammatory and antitumor activities^[1]. The antitumor activity of Arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene^[2].

IC₅₀ & Target

NLRP3

Ver todos los productos específicos de isoformas NOD-like Receptor (NLR) :

Cellular Effect

Cell Line	Type	Value	Description	References
518A2	IC₅₀	6.72 μM Compound: 203	Cytotoxicity against human 518A2 cells assessed as reduction in cell viability after 96 hrs by SRB asssay Cytotoxicity against human 518A2 cells assessed as reduction in cell viability after 96 hrs by SRB asssay	[PMID: 27996267]
A2780	IC₅₀	12.55 μM Compound: 11m	Cytotoxicity against human A2780 cells assessed as inhibition of cell growth incubated for 96 hrs by SRB assay Cytotoxicity against human A2780 cells assessed as inhibition of cell growth incubated for 96 hrs by SRB assay	[PMID: 32526552]
A-431	IC₅₀	4.48 μM Compound: 203	Cytotoxicity against human A431 cells assessed as reduction in cell viability after 96 hrs by SRB asssay Cytotoxicity against human A431 cells assessed as reduction in cell viability after 96 hrs by SRB asssay	[PMID: 27996267]
A549	IC₅₀	2.21 μM Compound: 203	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 96 hrs by SRB asssay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 96 hrs by SRB asssay	[PMID: 27996267]
HT-29	IC₅₀	7 μM Compound: 203	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 96 hrs by SRB asssay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 96 hrs by SRB asssay	[PMID: 27996267]
MCF7	IC₅₀	2.33 μM Compound: 203	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 96 hrs by SRB asssay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 96 hrs by SRB asssay	[PMID: 27996267]

In Vitro

The antitumor activity of arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene, a process that is believed to play a pivotal role in 20-30% of all human tumors. It actually inhibits the incorporation of farnesyl pyrophosphate into human H-ras proteins by the enzyme farnesyl transferase (FTase)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Arglabin reduces inflammation and plasma lipids, increases autophagy, and orients tissue macrophages into an anti-inflammatory phenotype in ApoE2.Ki mice fed a high-fat diet^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 84692-91-1
Appearance Solid
Peso molecular 246.31
Fòrmula C₁₅H₁₈O₃
Color White to light yellow
SMILES

C[C@]1(CC[C@](C2=C)([H])[C@@](OC2=O)([H])[C@@]3([H])C(C)=CC4)[C@]34O1
Synonyms

(+)-Arglabin
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
- Plants
- Compositae
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : ≥ 100 mg/mL (406.00 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.0600 mL

20.3000 mL

40.5999 mL

5 mM

0.8120 mL

4.0600 mL

8.1200 mL

10 mM

0.4060 mL

2.0300 mL

4.0600 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (10.15 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (10.15 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (10.15 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (277 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Abderrazak A, et al. Anti-inflammatory and antiatherogenic effects of the NLRP3 inflammasome inhibitor arglabin in ApoE2.Ki mice fed a high-fat diet. Circulation. 2015;131(12):1061-1070. [Content Brief]

[2]. Lone SH, et al. Arglabin: From isolation to antitumor evaluation. Chem Biol Interact. 2015;240:180-198. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.0600 mL	20.3000 mL	40.5999 mL	101.4998 mL
	5 mM	0.8120 mL	4.0600 mL	8.1200 mL	20.3000 mL
	10 mM	0.4060 mL	2.0300 mL	4.0600 mL	10.1500 mL
	15 mM	0.2707 mL	1.3533 mL	2.7067 mL	6.7667 mL
	20 mM	0.2030 mL	1.0150 mL	2.0300 mL	5.0750 mL
	25 mM	0.1624 mL	0.8120 mL	1.6240 mL	4.0600 mL
	30 mM	0.1353 mL	0.6767 mL	1.3533 mL	3.3833 mL
	40 mM	0.1015 mL	0.5075 mL	1.0150 mL	2.5375 mL
	50 mM	0.0812 mL	0.4060 mL	0.8120 mL	2.0300 mL
	60 mM	0.0677 mL	0.3383 mL	0.6767 mL	1.6917 mL
	80 mM	0.0507 mL	0.2537 mL	0.5075 mL	1.2687 mL
	100 mM	0.0406 mL	0.2030 mL	0.4060 mL	1.0150 mL

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Arglabin

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Drug Repurposing Compound Library

Ver todos los productos específicos de isoformas NOD-like Receptor (NLR)

Actividad biológica

Chemical Information

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

Arglabin Related Classifications

HY-16059 Related Classifications