Referencia número: HY-N2033

Chebulinic acid

4 Cited Publications

Revisión del cliente

Based on 4 publication(s) in Google Scholar

Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

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Pureza: 99.68%
No. CAS: 18942-26-2
Fòrmula: C₄₁H₃₂O₂₇
Peso molecular:956.68

Almacenamiento:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Chebulinic acid Chemical Structure

No. CAS: 18942-26-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (4)
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

IC₅₀ & Target

target: M. tuberculosis DNA gyrase[1], SMAD-3 phosphorylation[2], H+ K+-ATPase activity.[3] IC50: 65.01 μg/ml ( H+ K+-ATPase ) [3]

Ver todos los productos específicos de isoformas DNA/RNA Synthesis :

Ver todos los productos específicos de isoformas TGF-beta/Smad :

Smad1
Smad3

In Vitro

In vitro: binding of Chebulinic acid causes displacement of catalytic Tyr129 away from its target DNA-phosphate molecule. [1] Chebulinic acid reduce the expression and activity of MMP-2 at an ED50 value of 100 μM. EMT (Epithelial to Mesenchymal Transition) is found to be induced in ARPE-19 cells, through SMAD-3 phosphorylation and it is inhibited by CA. [2] chebulinic acid significantly inhibited H+ K+-ATPase activity in vitrowith IC50 of 65.01 μg/ml. [3]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 18942-26-2
Appearance Solid
Peso molecular 956.68
Fòrmula C₄₁H₃₂O₂₇
Color White to off-white
SMILES

OC(C[C@H](C(O[C@@]([C@H](O[C@H]1OC(C2=CC(O)=C(O)C(O)=C2)=O)COC(C3=CC(O)=C(O)C(O)=C3)=O)([H])[C@@](OC(C4=CC(O)=C(O)C(O)=C4)=O)([H])[C@@]1([H])OC5=O)=O)[C@@]([C@H]6O)([H])C(C5=CC(O)=C7O)=C7OC6=O)=O
Structure Classification
- Phenols
- Polyphenols
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (4)

All Cell Proliferation/Viability AssayELISART-PCRIn Vivo Efficacy StudyWB

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Journal Impact Factor

Acta Pharmacol Sin

Salvianolic acid A from Salvia miltiorrhiza identified as a cap-dependent endonuclease inhibitor for pathogenic arenaviruses. [Abstract]

2025 Sep 3. PMID: 40903541

Chebulinic acid purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2025 Sep 3. [Abstract]

Body weight changes in Female BALB/c mice aged 6–8 weeks after treatment with 20 mg/kg of Salvianolic acid A (SAA), Chebulinic Acid, Tannic acid, or Punicalagin via i.g. upon challenge once daily for 3 days. 300 mg/kg T-705 administered via i.g. was used as a positive control.

Chebulinic acid purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2025 Sep 3. [Abstract]

T-705 and SAA significantly reduced viral copies in the liver in Female BALB/c mice aged 6–8 weeks after treatment with 20 mg/kg of Salvianolic acid A (SAA), Chebulinic Acid, Tannic acid, or Punicalagin via i.g. upon challenge once daily for 3 days. 300 mg/kg T-705 administered via i.g. was used as a positive control.
Pharmaceutics

Inhibition of SARS-CoV-2-Induced NLRP3 Inflammasome-Mediated Lung Cell Inflammation by Triphala-Loaded Nanoparticle Targeting Spike Glycoprotein S1. [Abstract]

2024 Jun 2;16(6):751. PMID: 38931873

Chebulinic acid purchased from MedChemExpress. Usage Cited in: Pharmaceutics. 2024 Jun 2;16(6):751. [Abstract]

Chebulinic acid (0-50 μg/mL; 24, 48 h) showed no cytotoxicity towards A549 cells.

Chebulinic acid purchased from MedChemExpress. Usage Cited in: Pharmaceutics. 2024 Jun 2;16(6):751. [Abstract]

A549 cells were pre-treated with active compounds (Gallic acid, Chebulagic acid, and Chebulinic acid) (0–20 µg/mL) for 24 h. Then, the cells were exposed to CoV2-SP (100 ng/mL) for 3 h. The IL-6 (A), IL-1β (B), and IL-18 secretions (C) in the culture supernatant were examined by ELISA.

Chebulinic acid purchased from MedChemExpress. Usage Cited in: Pharmaceutics. 2024 Jun 2;16(6):751. [Abstract]

Inhibitory effects of active compounds (Gallic acid, Chebulagic acid and Chebulinic acid) on the IL-6 (A), IL-1β (B), IL-18 (C), and NLRP3 gene expressions (D) in CoV2-SP-induced A549 cells. A549 cells were pre-treated with active compounds (gallic acid, chebulagic acid and chebulinic acid) (0–20 µg/mL) for 24 h. Then, the cells were exposed to CoV2-SP (100 ng/mL) for 3 h. The mRNA expressions were determined using RT-qPCR.

Chebulinic acid purchased from MedChemExpress. Usage Cited in: Pharmaceutics. 2024 Jun 2;16(6):751. [Abstract]

The effects of Chebulagic acid and chebulinic acid inhibited the NLRP3 inflammasome pathway in CoV2-SP-induced A549 cells. A549 cells were pre-treated with chebulagic acid and Chebulinic acid (0–20 µg/mL) for 24 h. Then, the cells were exposed to CoV2-SP (100 ng/mL) for 3 h. The inhibitory effects of chebulagic acid and chebulinic acid on the expression of NLRP3, ASC, and pro-caspase-1 (p50) and cleaved-caspase-1 (p20) proteins in A549 cells are displayed in western blot.
J Chromatogr A

Screening and identification of acetylcholinesterase inhibitors from Terminalia chebula fruits by immobilized enzyme on cellulose filter paper coupled with ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry and molecular docking. [Abstract]

2022 Jan 25:1663:462784. PMID: 34974370
Ren Fail

Targeting LRH-1 alleviates diabetes-induced lipotoxicity in podocytes: role of PLIN5-mediated lipid droplet turnover. [Abstract]

2026 Dec;48(1):2670806. PMID: 42135621

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (104.53 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.0453 mL

5.2264 mL

10.4528 mL

5 mM

0.2091 mL

1.0453 mL

2.0906 mL

10 mM

0.1045 mL

0.5226 mL

1.0453 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (287 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Patel K et al. Identification of chebulinic acid as potent natural inhibitor of M. tuberculosis DNA gyrase and molecular insights into its binding mode of action. Comput Biol Chem. 2015 Dec;59 Pt A:37-47. [Content Brief]

[2]. Sivasankar S et al. Aqueous and alcoholic extracts of Triphala and their active compounds chebulagic acid and chebulinic acidprevented epithelial to mesenchymal transition in retinal pigment epithelial cells, by inhibiting SMAD-3 phosphorylation. PLoS One. 2015 Mar 20 [Content Brief]

[3]. Mishra V et al. Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers. Phytomedicine. 2013 Apr 15;20(6):506-11. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.0453 mL	5.2264 mL	10.4528 mL	26.1320 mL
	5 mM	0.2091 mL	1.0453 mL	2.0906 mL	5.2264 mL
	10 mM	0.1045 mL	0.5226 mL	1.0453 mL	2.6132 mL
	15 mM	0.0697 mL	0.3484 mL	0.6969 mL	1.7421 mL
	20 mM	0.0523 mL	0.2613 mL	0.5226 mL	1.3066 mL
	25 mM	0.0418 mL	0.2091 mL	0.4181 mL	1.0453 mL
	30 mM	0.0348 mL	0.1742 mL	0.3484 mL	0.8711 mL
	40 mM	0.0261 mL	0.1307 mL	0.2613 mL	0.6533 mL
	50 mM	0.0209 mL	0.1045 mL	0.2091 mL	0.5226 mL
	60 mM	0.0174 mL	0.0871 mL	0.1742 mL	0.4355 mL
	80 mM	0.0131 mL	0.0653 mL	0.1307 mL	0.3267 mL
	100 mM	0.0105 mL	0.0523 mL	0.1045 mL	0.2613 mL

Keywords

Chebulinic acid

4 Cited Publications

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Chebulinic acid

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Publications Citing Use of MedChemExpress (MCE) Chebulinic acid

Ver todos los productos específicos de isoformas DNA/RNA Synthesis

Ver todos los productos específicos de isoformas TGF-beta/Smad

Actividad biológica

Chemical Information

Publications (4)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

Chebulinic acid Related Classifications

HY-N2033 Related Classifications