Eleutheroside E
Based on 2 publication(s) in Google Scholar
Eleutheroside E is an important component of ginseng that can be taken orally. Eleutheroside E has anti-inflammatory and antioxidant properties, and it helps reduce apoptosis in heart cells caused by hypoxia-reoxygenation (H/R) damage. Eleutheroside E can improve type 2 diabetes, enhance cognitive function, and has neuroprotective effects.
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- Pureza: 99.60%
- No. CAS: 39432-56-9
- Fòrmula: C34H46O18
- Peso molecular:742.72
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Eleutheroside E
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Actividad biológica
Eleutheroside E (10 μM, 24 h) increases insulin-induced glucose uptake in C2C12 myotubes and improves the inhibition of glucose uptake by TNF-α in 3T3-L1 adipocytes[1].
Eleutheroside E (0-100 μM, 3 h) enhances cell viability in H9c2 cells subjected to H/R injury[2].
Eleutheroside E (0-100 μM, 12 h) has a protective effect against apoptosis in H9c2 cells induced by H/R injury[2].
Eleutheroside E (100 μM, 12 h) boosts antioxidant capacity in H9c2 cells[2].
Eleutheroside E (100 μM, 12 h) blocks the MAPK pathway and inhibits the activation of NF-κB[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:H9c2, H9c2 (H/r)
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Concentration:0, 30, 60, 100 μM
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Incubation Time:3 h
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Result:Enhanced the cell viability of H9c2 (H/r) cells in a dose-dependent manner and had no effect on normal cells.
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Cell Line:H9c2 (H/r)
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Concentration:100 μM
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Incubation Time:12 h
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Result:Reduced the expression of Bax, caspase-3 and caspase-9, and enhanced the expression of Bcl-2. Reduced the expression of Cyt-Cyto-C, reduced the levels of LDH and HMGB1 induced by H2O2, and inhibited the phosphorylation of ERK, JNK and p38.
Eleutheroside E (15-60 mg/kg, oral, once daily, three weeks) alleviates arthritis in a collagen-induced arthritis mouse model[3].
Eleutheroside E (50 mg/kg, oral, once daily, four weeks) prevents cognitive deficits caused by radiation in mice[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:db/db mice[1]
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Dosage:Containing 0.003% of the diet; 5 weeks
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Administration:Oral
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Result:Improved blood lipids, significantly reduced blood sugar and serum insulin levels, induced HOMA-IR, increased insulin sensitivity, and protected pancreatic α and β cells from diabetic damage.
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Animal Model:Collageninduced arthritis (CIA) mice[3]
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Dosage:15, 30, 60 mg/kg; daily; 3 weeks
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Administration:Oral
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Result:Reduced mean arthritis score and arthritis incidence, reduced inflammatory cell infiltration, mesenchymal formation, cartilage damage and bone erosion in CIA mice, and decreased TNF-α and IL-6.
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Animal Model:Mice irradiated with 60Co-γ rays[4]
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Dosage:50 mg/kg; daily; 4 weeks
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Administration:Oral
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Result:Improved cognitive and spatial memory impairments in irradiated mice, protected hippocampal neurons, and activated the PKA/CREB/BDNF signaling pathway.
Chemical Information
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No. CAS 39432-56-9
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Appearance Solid
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Peso molecular 742.72
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Fòrmula C34H46O18
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Color White to off-white
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SMILES
COC(C=C1[C@H]2[C@@](CO[C@@H]3C4=CC(OC)=C(O[C@@H]([C@@H]([C@@H](O)[C@@H]5O)O)O[C@@H]5CO)C(OC)=C4)([H])[C@]3([H])CO2)=C(C(OC)=C1)O[C@@H]([C@@H]([C@@H](O)[C@@H]6O)O)O[C@@H]6CO
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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J Pharm Pharmacol
Eleutheroside E functions as anti-cervical cancer drug by inhibiting the phosphatidylinositol 3-kinase pathway and reprogramming the metabolic responses. [Abstract]2022 Sep 1;74(9):1251-1260. PMID: 35789274
Solvente y solubilidad
DMSO : 100 mg/mL (134.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 1 mg/mL (1.35 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.37 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.37 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (285 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[3]. Wang S, et al. Eleutheroside E decreases oxidative stress and NF-κB activation and reprograms the metabolic response against hypoxia-reoxygenation injury in H9c2 cells. Int Immunopharmacol. 2020 Jul;84:106513. [Content Brief]
[4]. Chen Song, et al. Eleutheroside E supplementation prevents radiation-induced cognitive impairment and activates PKA signaling via gut microbiota. Commun Biol. 2022 Jul 8;5(1):680. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.3464 mL | 6.7320 mL | 13.4640 mL | 33.6601 mL |
| DMSO | 5 mM | 0.2693 mL | 1.3464 mL | 2.6928 mL | 6.7320 mL |
| 10 mM | 0.1346 mL | 0.6732 mL | 1.3464 mL | 3.3660 mL | |
| 15 mM | 0.0898 mL | 0.4488 mL | 0.8976 mL | 2.2440 mL | |
| 20 mM | 0.0673 mL | 0.3366 mL | 0.6732 mL | 1.6830 mL | |
| 25 mM | 0.0539 mL | 0.2693 mL | 0.5386 mL | 1.3464 mL | |
| 30 mM | 0.0449 mL | 0.2244 mL | 0.4488 mL | 1.1220 mL | |
| 40 mM | 0.0337 mL | 0.1683 mL | 0.3366 mL | 0.8415 mL | |
| 50 mM | 0.0269 mL | 0.1346 mL | 0.2693 mL | 0.6732 mL | |
| 60 mM | 0.0224 mL | 0.1122 mL | 0.2244 mL | 0.5610 mL | |
| 80 mM | 0.0168 mL | 0.0842 mL | 0.1683 mL | 0.4208 mL | |
| 100 mM | 0.0135 mL | 0.0673 mL | 0.1346 mL | 0.3366 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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