Referencia número: HY-13861

GW7647

25 Cited Publications

Revisión del cliente

Based on 25 publication(s) in Google Scholar

GW7647 is a potent PPARα agonist, with EC₅₀s of 6 nM, 1.1 μM, and 6.2 μM for human PPARα, PPARγ and PPARδ, respectively.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 99.45%
No. CAS: 265129-71-3
Fòrmula: C₂₉H₄₆N₂O₃S
Peso molecular:502.75

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

GW7647 Chemical Structure

No. CAS: 265129-71-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (25)
Solvente y solubilidad
- In Vitro
- In Vivo
Protocolo
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

GW7647 is a potent PPARα agonist, with EC₅₀s of 6 nM, 1.1 μM, and 6.2 μM for human PPARα, PPARγ and PPARδ, respectively.

IC₅₀ & Target^[5]

PPARα

6 nM (EC₅₀, Human PPARα)

PPARγ

1.1 μM (EC₅₀, Human PPARγ)

PPARδ

6.2 μM (EC₅₀, Human PPARδ)

Ver todos los productos específicos de isoformas PPAR :

Cellular Effect

Cell Line	Type	Value	Description	References
COS-7	EC₅₀	0.2 μM Compound: GW7647	Transactivation of GAL4-fused human PPARalpha ligand binding domain transfected in african green monkey COS7 cells by luciferase reporter gene assay Transactivation of GAL4-fused human PPARalpha ligand binding domain transfected in african green monkey COS7 cells by luciferase reporter gene assay	[PMID: 23130964]
COS-7	EC₅₀	0.2 μM Compound: GW7647	Transactivation of human PPARalpha expressed in African green monkey COS7 cells incubated overnight by dual-glo luciferase reporter gene assay Transactivation of human PPARalpha expressed in African green monkey COS7 cells incubated overnight by dual-glo luciferase reporter gene assay	[PMID: 26595749]
COS-7	EC₅₀	0.23 μM Compound: GW7647	Agonist activity at wild-type human PPARalpha LBD expressed in COS7 cells after 12 hrs by Dual-Glo luciferase assay Agonist activity at wild-type human PPARalpha LBD expressed in COS7 cells after 12 hrs by Dual-Glo luciferase assay	[PMID: 25022880]
COS-7	EC₅₀	0.23 μM Compound: GW-7647	Transactivation of human PPARalpha LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Luciferase reporter gene assay Transactivation of human PPARalpha LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Luciferase reporter gene assay	[PMID: 20307981]
COS-7	EC₅₀	0.25 μM Compound: GW7647	Agonist activity at wild-type human PPARalpha Thr279Ala mutant expressed in COS7 cells after 12 hrs by Dual-Glo luciferase assay Agonist activity at wild-type human PPARalpha Thr279Ala mutant expressed in COS7 cells after 12 hrs by Dual-Glo luciferase assay	[PMID: 25022880]
CV-1	EC₅₀	0.006 μM Compound: GW-7647	In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR alpha ligand binding domain In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR alpha ligand binding domain	[PMID: 11354382]
CV-1	EC₅₀	1.1 μM Compound: GW-7647	In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR gamma ligand binding domain In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR gamma ligand binding domain	[PMID: 11354382]
CV-1	EC₅₀	6.2 μM Compound: GW-7647	In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR delta ligand binding domain In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR delta ligand binding domain	[PMID: 11354382]
HEK293	EC₅₀	0.021 μM Compound: GW7647	Agonist activity at GAL4-tagged human PPARalpha ligand binding domain chimeric receptor expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay Agonist activity at GAL4-tagged human PPARalpha ligand binding domain chimeric receptor expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay	[PMID: 27591006]
HEK293	EC₅₀	0.021 μM Compound: GW7647	Agonist activity at N-terminal Gal4 fused human PPARalpha LBD transfected in HEK293 cells after 24 hrs by luciferase reporter gene assay Agonist activity at N-terminal Gal4 fused human PPARalpha LBD transfected in HEK293 cells after 24 hrs by luciferase reporter gene assay	[PMID: 27622746]
HEK293	EC₅₀	0.026 μM Compound: GW7647	Agonist activity at GAL4N fused human PPARalpha LBD expressed in HEK293 cells co-expressing TK-MH100x4-Luc after 24 hrs by luciferase reporter gene assay Agonist activity at GAL4N fused human PPARalpha LBD expressed in HEK293 cells co-expressing TK-MH100x4-Luc after 24 hrs by luciferase reporter gene assay	[PMID: 28539218]
HEK293	EC₅₀	0.2 μM Compound: 1, GW-7647	Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assay Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assay	[PMID: 19791744]
HEK293	EC₅₀	0.2 μM Compound: 3, GW7647	Transactivation of human GAL4-fused PPARalpha ligand binding domain transfected in HEK293 cells after 18 hrs by dual luciferase reporter gene assay Transactivation of human GAL4-fused PPARalpha ligand binding domain transfected in HEK293 cells after 18 hrs by dual luciferase reporter gene assay	[PMID: 23102891]
HEK293	EC₅₀	0.2 μM Compound: GW-7647	Agonist activity at PPARalpha ligand binding domain expressed in HEK293 cells co-expressing GAL4 after 18 hrs by dual-luciferase activity based transactivation assay Agonist activity at PPARalpha ligand binding domain expressed in HEK293 cells co-expressing GAL4 after 18 hrs by dual-luciferase activity based transactivation assay	[PMID: 21742490]
HEK293	EC₅₀	0.2 μM Compound: GW-7647	Agonist activity at Gal4-fused PPARalpha expressed in HEK293 cells after 18 hrs by dual luciferase reporter gene assay Agonist activity at Gal4-fused PPARalpha expressed in HEK293 cells after 18 hrs by dual luciferase reporter gene assay	[PMID: 21889235]
HEK293	EC₅₀	0.6 nM Compound: GW7647	Activation of PPARalpha transfected in HEK293 cells after 18 hrs by firefly luciferase reporter gene-based luminescence assay relative to control Activation of PPARalpha transfected in HEK293 cells after 18 hrs by firefly luciferase reporter gene-based luminescence assay relative to control	[PMID: 21800856]
HEK293	EC₅₀	0.89 nM Compound: GW7647	Agonist activity at human PPARalpha expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at human PPARalpha expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 25305688]
HEK293	EC₅₀	13.6 nM Compound: GW7647	Agonist activity at PPAR-alpha (unknown origin) expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at PPAR-alpha (unknown origin) expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 24856059]
HEK293	EC₅₀	7.1 nM Compound: GW7647	Agonist activity at PPAR-alpha (unknown origin) expressed in HEK293 cells by TR-FRET assay Agonist activity at PPAR-alpha (unknown origin) expressed in HEK293 cells by TR-FRET assay	[PMID: 24856059]
HEK293	IC₅₀	0.46 nM Compound: GW7647	Agonist activity at PPARalpha-LBD expressed in HEK293 cells co-expressing GAL4-DBD after 16 to 19 hrs by beta lactamase reporter gene assay Agonist activity at PPARalpha-LBD expressed in HEK293 cells co-expressing GAL4-DBD after 16 to 19 hrs by beta lactamase reporter gene assay	[PMID: 22939697]
HEK293-A	EC₅₀	0.2 μM Compound: 8, GW7674	Transactivation of PPARalpha expressed in HEK293A cells co-expressing GAL4 after 16 to 18 hrs by luciferase reporter gene assay Transactivation of PPARalpha expressed in HEK293A cells co-expressing GAL4 after 16 to 18 hrs by luciferase reporter gene assay	[PMID: 23137448]
HEK-293T	EC₅₀	15.4 nM Compound: GW7647	Agonist activity at GAL4-tagged PPARalpha ligand-binding domain (unknown origin) expressed in HEK293T cells incubated for 16 to 19 hrs by beta-lactamase reporter gene assay Agonist activity at GAL4-tagged PPARalpha ligand-binding domain (unknown origin) expressed in HEK293T cells incubated for 16 to 19 hrs by beta-lactamase reporter gene assay	[PMID: 25491112]
MCF7	EC₅₀	178 nM Compound: GW-7647	Agonist activity at human PPARalpha expressed in human MCF7 cells coexpressing TIF2 by luciferase reporter gene assay Agonist activity at human PPARalpha expressed in human MCF7 cells coexpressing TIF2 by luciferase reporter gene assay	[PMID: 18952442]
MCF7	EC₅₀	6.5 nM Compound: GW7647	Agonist activity at human PPARalpha transfected in human MCF7 cells after 16 hrs by luciferase reporter gene assay Agonist activity at human PPARalpha transfected in human MCF7 cells after 16 hrs by luciferase reporter gene assay	[PMID: 26226490]

In Vitro

GW7647 (1 μM) causes a significant increase of PDZK1 protein expression to 129.7 ± 6.5% of vehicle treated control in Caco2BBE cells in the absence and presence of IL-1β. GW7647 also attenuates the IL-1β-mediated decrease in PDZK1 expression^[1].
GW7647 (50 nM) stimulates the PI3K phosphorylation followed by the Akt (Ser473) phosphorylation, which induces NOS1 phosphorylation increased the amounts of NO released in the stripped antral mucosa. GW7647 (50 nM) enhances the initial phase of Ca²⁺-regulated exocytotic events stimulated by ACh in antral mucous cells, but GW7647 alone does not evoke any exocytotic event. GW7647 plus ACh stimulates the effects of wortmannin (50 nM) and AKT-inh (100 nM) on the exocytotic events in antral mucous cells^[2].
GW 7647 (100 nM) reduces the AQP9 protein abundance by 43%, but it shows not significant effect at 10 and 1,000 nM in WIF-B9 hepatocytes. GW 7647 (100 nM) causes a 24% reduction in AQP9 protein abundance in HepG2 cells, however, it does not significantly increase the protein abundance of L-FABP in HepG2 hepatocytes^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GW7647 (3 mg/kg per day) does not prevent the development of cardiac hypertrophy, but it prevents the decline in left ventricular ejection fraction in vivo^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 265129-71-3
Appearance Solid
Peso molecular 502.75
Fòrmula C₂₉H₄₆N₂O₃S
Color White to off-white
SMILES

CC(C)(SC1=CC=C(CCN(C(NC2CCCCC2)=O)CCCCC3CCCCC3)C=C1)C(O)=O
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (25)

All In Vivo Efficacy StudyRT-PCRHistological Imaging/StainingCell Imaging/StainingWB

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Journal Impact Factor

Cell Metab

The enedioic acid analog 326E alleviates metabolic dysfunction-associated steatohepatitis via dual targeting at ACLY and PPARα. [Abstract]

2025 Oct 22:S1550-4131(25)00396-1. PMID: 41130202
Nat Commun

Ascites protects against ferroptosis and enables the peritoneal growth of ovarian cancer. [Abstract]

2026 May 11;17(1):4190. PMID: 42115216
Theranostics

Dysregulation of interaction between LOXhigh fibroblast and smooth muscle cells contributes to the pathogenesis of aortic dissection. [Abstract]

2022 Jan 1;12(2):910-928. PMID: 34976220

GW7647 purchased from MedChemExpress. Usage Cited in: Theranostics. 2022 Jan 1;12(2):910-928. [Abstract]

GW7647 (10 mg/kg; Apply as a gel to the aortic arch). Systolic blood pressure at different time points following treatment.
Exp Mol Med

LncRNA Gm35585 transcriptionally activates the peroxidase EHHADH against diet-induced fatty liver. [Abstract]

2025 Mar;57(3):652-666. PMID: 40082671

GW7647 purchased from MedChemExpress. Usage Cited in: Exp Mol Med. 2025 Mar;57(3):652-666. [Abstract]

GW7647 (5 μM; 24 h). mRNA expression levels of Pparα and Ehhadh with PA and GW7647 treatment in AML-12 cells.

GW7647 purchased from MedChemExpress. Usage Cited in: Exp Mol Med. 2025 Mar;57(3):652-666. [Abstract]

GW7647 (5 μM; 24 h). Nile Red staining of AML-12 cells to test changes in lipid content.

GW7647 purchased from MedChemExpress. Usage Cited in: Exp Mol Med. 2025 Mar;57(3):652-666. [Abstract]

GW7647 (5 μM; 24 h). The protein expression of PPARα and EHHADH in AML-12 cells.
Pharmacol Res

A novel FFA1 agonist, CPU025, improves glucose-lipid metabolism and alleviates fatty liver in obese-diabetic (ob/ob) mice. [Abstract]

2020 Mar;153:104679. PMID: 32014571
Acta Pharmacol Sin

Targeting PPARα activation sensitizes glioblastoma cells to temozolomide and reverses acquired resistance by inhibiting H3K18 lactylation. [Abstract]

2025 Jun 11. PMID: 40500345
Br J Pharmacol

HWL-088, a new potent free fatty acid receptor 1 (FFAR1) agonist, improves glucolipid metabolism and acts additively with metformin in ob/ob diabetic mice. [Abstract]

2020 May;177(10):2286-2302. PMID: 31971610
JHEP Rep

2026 May 5.
Biomed Pharmacother

Propofol pretreatment inhibits ferroptosis and alleviates myocardial ischemia-reperfusion injury through the SLC16A13-AMPK-GPX4 pathway. [Abstract]

2024 Aug 28:179:117345. PMID: 39208667

GW7647 purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Aug 28:179:117345. [Abstract]

GW7647 (10 mg/kg; jugular vein injection). Histopathological pictures of heart tissue sections were stained with H&E.

GW7647 purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Aug 28:179:117345. [Abstract]

GW7647 (50 μM; 24 h). Causing cell morphology under the microscope.
Cell Chem Biol

Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2. [Abstract]

2021 Jun 17;28(6):855-865.e9. PMID: 33979649
J Med Chem

Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPARα/δ Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis. [Abstract]

2022 Feb 10;65(3):2571-2592. PMID: 35060744
Eur J Med Chem

Design, synthesis, and biological evaluation of imidazolidinone derivatives as potent PPARα/δ agonists for the treatment of cholestatic liver diseases. [Abstract]

2025 Jan 15:286:117284. PMID: 39827490
Eur J Med Chem

Design, synthesis, and biological evaluation of piperazine derivatives as pan-PPARs agonists for the treatment of liver fibrosis. [Abstract]

2024 Apr 5:269:116344. PMID: 38522113
Eur J Med Chem

Discovery of new and highly effective quadruple FFA1 and PPARα/γ/δ agonists as potential anti-fatty liver agents. [Abstract]

2022 Feb 5:229:114061. PMID: 34954593
Eur J Med Chem

Discovery of the first-in-class dual PPARδ/γ partial agonist for the treatment of metabolic syndrome. [Abstract]

2021 Dec 5:225:113807. PMID: 34455359
Eur J Pharmacol

Hepatoprotective effects of ZLY16, a dual peroxisome proliferator-activated receptor α/δ agonist, in rodent model of nonalcoholic steatohepatitis. [Abstract]

2020 Sep 5;882:173300. PMID: 32592770
Rheumatology (Oxford)

FTY720 ameliorates experimental MPO-ANCA-associated vasculitis by regulating fatty acid oxidation via the neutrophil PPARα-CPT1a pathway. [Abstract]

2024 Jun 5:keae320. PMID: 38837706
Animal

Oleic acid promotes lipid accumulation in bovine adipocytes: the role of peroxisome proliferator-activated receptor alpha (PPARα) signaling. [Abstract]

2025 Apr 3;19(5):101505. PMID: 40300479
Drug Dev Res

Downregulation of CPT1A exerts a protective effect in dextran sulfate sodium-induced ulcerative colitis partially by inhibiting PPARα signaling pathway. [Abstract]

2022 Sep;83(6):1408-1418. PMID: 35749635
Biochim Biophys Acta Mol Basis Dis

LAZ3 protects cardiac remodeling in diabetic cardiomyopathy via regulating miR-21/PPARa signaling. [Abstract]

2018 Oct;1864(10):3322-3338. PMID: 30031228
J Lipid Res

Lipotoxicity of palmitic acid is associated with DGAT1 downregulation and abolished by PPARα activation in liver cells. [Abstract]

2024 Nov 4:100692. PMID: 39505261
Transl Oncol

IGFBP1 promotes the proliferation and migration of lung adenocarcinoma cells through the PPARα pathway. [Abstract]

2024 Aug 20:49:102095. PMID: 39167955
Fish Shellfish Immunol

Perfluorooctanoic acid (PFOA) exposure induced ferroptosis through the PPARα/FABP7 signaling pathway in the liver of spotted sea bass (Lateolabrax maculatus). [Abstract]

2025 Oct 8:168:110908. PMID: 41067592
Sci Rep

Activation of PPAR-α attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis and mitochondrial injury via upregulating 14-3-3η. [Abstract]

2024 Jul 2;14(1):15246. PMID: 38956068
Bioorg Med Chem

Design, synthesis, and biological evaluation of novel dual FFA1 and PPARδ agonists possessing phenoxyacetic acid scaffold. [Abstract]

2022 Feb 15:56:116615. PMID: 35051813

Solvente y solubilidad

In Vitro:

DMSO : ≥ 60 mg/mL (119.34 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9891 mL

9.9453 mL

19.8906 mL

5 mM

0.3978 mL

1.9891 mL

3.9781 mL

10 mM

0.1989 mL

0.9945 mL

1.9891 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (4.97 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (4.97 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg
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g
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
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+
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The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Protocolo

Animal Administration^[4]

Newborn New Zealand White rabbits of either sex (7 days old, 90-200 g) are anesthetized with inhaled isofluorane (2%), and are subjected to an aorto-caval shunt to induce volume-overload cardiac hypertrophy. The presence of a successful fistula is verified at postsurgical days 7 and 13 by color flow doppler that visualizes a physical shunt between the abdominal aorta and the inferior vena cava in both an axial and transverse plane. This is further validated by an enlarged inferior vena cava. After validation, the animals in shunt group are randomly assigned to receive an intraperitoneal injection of vehicle (dimethyl sulfoxide, the solvent of GW7647) or GW7647 (3 mg/kg per day; EC₅₀=6 nM for PPARα) twice a day for 14 days. Animals that undergo surgery to create shunt, but consequently the shunt either not exhibiting or closed, are excluded from the study. Left ventricular ejection fraction (%) and other cardiac parameters are assessed by transthoracic echocardiography at postsurgical days 7 and 13. At 21 days of age (14 days post surgery), all animals are euthanized with Na⁺ pentobarbital, and hearts are removed for isolated biventricular working heart perfusions.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (282 KB)
SDS (252 KB)
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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Luo M, et al. IL-1β-Induced Downregulation of the Multifunctional PDZ Adaptor PDZK1 Is Attenuated by ERK Inhibition, RXRα, or PPARα Stimulation in Enterocytes. Front Physiol. 2017 Feb 7;8:61. [Content Brief]

[2]. Tanaka S, et al. PPARα induced NOS1 phosphorylation via PI3K/Akt in guinea pig antral mucous cells: NO-enhancement in Ca(2+)-regulated exocytosis. Biomed Res. 2016;37(3):167-78. [Content Brief]

[3]. Lebeck J, et al. Hepatic AQP9 expression in male rats is reduced in response to PPARα agonist treatment. Am J Physiol Gastrointest Liver Physiol. 2015 Feb 1;308(3):G198-205. [Content Brief]

[4]. Lam VH, et al. Activating PPARα prevents post-ischemic contractile dysfunction in hypertrophied neonatal hearts. Circ Res. 2015 Jun 19;117(1):41-51. [Content Brief]

[5]. Brown PJ, et al. Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis. Bioorg Med Chem Lett. 2001 May 7;11(9):1225-7. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9891 mL	9.9453 mL	19.8906 mL	49.7265 mL
	5 mM	0.3978 mL	1.9891 mL	3.9781 mL	9.9453 mL
	10 mM	0.1989 mL	0.9945 mL	1.9891 mL	4.9727 mL
	15 mM	0.1326 mL	0.6630 mL	1.3260 mL	3.3151 mL
	20 mM	0.0995 mL	0.4973 mL	0.9945 mL	2.4863 mL
	25 mM	0.0796 mL	0.3978 mL	0.7956 mL	1.9891 mL
	30 mM	0.0663 mL	0.3315 mL	0.6630 mL	1.6576 mL
	40 mM	0.0497 mL	0.2486 mL	0.4973 mL	1.2432 mL
	50 mM	0.0398 mL	0.1989 mL	0.3978 mL	0.9945 mL
	60 mM	0.0332 mL	0.1658 mL	0.3315 mL	0.8288 mL
	80 mM	0.0249 mL	0.1243 mL	0.2486 mL	0.6216 mL
	100 mM	0.0199 mL	0.0995 mL	0.1989 mL	0.4973 mL

Keywords

GW7647

25 Cited Publications

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GW7647

Cell Cycle/DNA Damage Compound Library

Metabolism/Protease Compound Library

Anti-Aging Compound Library

Anti-Cardiovascular Disease Compound Library

Pyroptosis Compound Library

Anti-Obesity Compound Library

Transcription Factor-Targeted Library

Lipid Metabolism Compound Library

Antidepressant Compound Library

Human Metabolite Library

Nuclear Receptor Compound Library

Osteogenesis Compound Library

Cancer Stem Cells Compound Library

Mitochondrial Protection Compound Library

Metabolic Enzyme Compound Library

Highly Selective Activators Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Publications Citing Use of MedChemExpress (MCE) GW7647

Ver todos los productos específicos de isoformas PPAR

Actividad biológica

Chemical Information

Publications (25)

Solvente y solubilidad

Protocolo

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

GW7647

Cell Cycle/DNA Damage Compound Library

Metabolism/Protease Compound Library

Anti-Aging Compound Library

Anti-Cardiovascular Disease Compound Library

Pyroptosis Compound Library

Anti-Obesity Compound Library

Transcription Factor-Targeted Library

Lipid Metabolism Compound Library

Antidepressant Compound Library

Human Metabolite Library

Nuclear Receptor Compound Library

Osteogenesis Compound Library

Cancer Stem Cells Compound Library

Mitochondrial Protection Compound Library

Metabolic Enzyme Compound Library

Highly Selective Activators Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Publications Citing Use of MedChemExpress (MCE) GW7647

Ver todos los productos específicos de isoformas PPAR

Actividad biológica

Chemical Information

Publications (25)

Solvente y solubilidad

Protocolo

Pureza y Documentación

Referencias

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Complete Stock Solution Preparation Table

GW7647 Related Classifications

HY-13861 Related Classifications