Otilonium bromide
Based on 3 publication(s) in Google Scholar
Otilonium bromide (OB) is an orally active mAChR inhibitor and smooth muscle relaxant which can interfere with the mobilization of calcium in intestinal smooth muscle, OB can be used for research of irritable bowel syndrome.
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- Pureza : 99.67%
- No. CAS: 26095-59-0
- Fòrmula: C29H43BrN2O4
- Peso molecular:563.57
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Otilonium bromide
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Actividad biológica
Descripciòn
In Vitro
Otilonium bromide (10 nM-100 μM) inhibits acetylcholine-induced human colonic crypt calcium signals in a dose dependent manner with an IC50 of 880 nM[2].
Otilonium bromide (30 µM) inhibits Ca2+ uptake in bovine chromaffin cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 26095-59-0
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Appearance Solid
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Peso molecular 563.57
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Fòrmula C29H43BrN2O4
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Color White to off-white
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SMILES
O=C(OCC[N+](CC)(CC)C)C1=CC=C(NC(C2=CC=CC=C2OCCCCCCCC)=O)C=C1.[Br-]
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Synonyms
Octylonium bromide; SP63
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Virulence
Otilonium bromide exhibits novel antifungal activity against Candida albicans via regulating iron homeostasis. [Abstract]2026 Dec;17(1):2609407. PMID: 41437513 -
Front Microbiol
Repurposing Antispasmodic Agent Otilonium Bromide for Treatment of Staphylococcus aureus Infections. [Abstract]2020 Jul 31:11:1720. PMID: 32849366 -
ACS Chem Neurosci
Identification of FDA-Approved Small Molecules Capable of Disrupting the Calmodulin-Adenylyl Cyclase 8 Interaction through Direct Binding to Calmodulin. [Abstract]2018 Feb 21;9(2):346-357. PMID: 28968502
Solvente y solubilidad
In Vitro:
H2O : ≥ 100 mg/mL (177.44 mM)
DMSO : 50 mg/mL (88.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.44 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Battaglia, G., et al., Otilonium bromide in irritable bowel syndrome: a double-blind, placebo-controlled, 15-week study. Aliment Pharmacol Ther, 1998. 12(10): p. 1003-10. [Content Brief]
[3]. Gandia, L., et al., Otilonium: a potent blocker of neuronal nicotinic ACh receptors in bovine chromaffin cells. Br J Pharmacol, 1996. 117(3): p. 463-470. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.7744 mL | 8.8720 mL | 17.7440 mL | 44.3601 mL |
| 5 mM | 0.3549 mL | 1.7744 mL | 3.5488 mL | 8.8720 mL | |
| 10 mM | 0.1774 mL | 0.8872 mL | 1.7744 mL | 4.4360 mL | |
| 15 mM | 0.1183 mL | 0.5915 mL | 1.1829 mL | 2.9573 mL | |
| 20 mM | 0.0887 mL | 0.4436 mL | 0.8872 mL | 2.2180 mL | |
| 25 mM | 0.0710 mL | 0.3549 mL | 0.7098 mL | 1.7744 mL | |
| 30 mM | 0.0591 mL | 0.2957 mL | 0.5915 mL | 1.4787 mL | |
| 40 mM | 0.0444 mL | 0.2218 mL | 0.4436 mL | 1.1090 mL | |
| 50 mM | 0.0355 mL | 0.1774 mL | 0.3549 mL | 0.8872 mL | |
| 60 mM | 0.0296 mL | 0.1479 mL | 0.2957 mL | 0.7393 mL | |
| 80 mM | 0.0222 mL | 0.1109 mL | 0.2218 mL | 0.5545 mL | |
| H2O | 100 mM | 0.0177 mL | 0.0887 mL | 0.1774 mL | 0.4436 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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