ABS-752
ABS-752 is a potent and orally active GSPT1 and NEK7 molecular glue degrader. ABS-752 shows cytotoxicity. ABS-752 decreases the protein expression of GSPT1 and SALL4, NEK7. ABS-752 is a prodrug activated by the monoamine oxidase, VAP-1, to an aldehyde intermediate and subsequently to the active molecule, ABT-002 (HY-175283). ABS-752 has the potential for the research of hepatocellular carcinoma.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2761170-84-5
- Fòrmula: C14H14FN3O3
- Peso molecular:291.28
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:NSG mice (Hep3B cells)[1]
-
Dosage:1, 3, 10 mg/kg
-
Administration:Po; daily for 14 days
-
Result:Showed anticancer activity in a dose-dependent manner.
Chemical Information
-
No. CAS 2761170-84-5
-
Peso molecular 291.28
-
Fòrmula C14H14FN3O3
-
SMILES
O=C(C(N(CC1=C2C=C(F)C(CN)=C1)C2=O)CC3)NC3=O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ABS-752 Related Classifications
HY-W599279 Related Classifications
Powered by Bioz