ADS032
Based on 4 publication(s) in Google Scholar
ADS032 is a sulfonylurea compound that is an NLRP1 and NLRP3 inflammasome inhibitor. ADS032 reduces the secretion of inflammatory factors and inhibits the oligomerization of ASC. ADS032 has anti-inflammatory effects in a variety of inflammatory models and can be used in the study of inflammatory diseases.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.89%
- No. CAS: 2757333-37-0
- Fòrmula: C22H29NO4S
- Peso molecular:403.53
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) ADS032
More
Actividad biológica
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NLRP1 |
NLRP3 |
ADS032 (20 mg/kg; nasal administration; 2-3 doses) protects mice from severe IAV disease and reduces lung inflammation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:LPS (HY-D1056) treated C57BL/6 mice [1]
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Dosage:200 mg/kg
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Administration:Intraperitoneal injection (i.p.); single dose
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Result:Significantly reduced levels of circulating inflammatory cytokines IL-1β, TNF-α and IFN-γ, while IL-10 was not affected.
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Animal Model:HKx31 (an IAV relative to PR8) treated C57BL/6 mice[1]
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Dosage:20 mg/kg
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Administration:Nasal administration; 2-3 doses: days 1, 3 and 5 or days 3 and 5 post-IAV infection (day 0)
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Result:Reduced the weight loss and mortality of mice.
Did not induce any noticeable pulmonary inflammation itself.
Reduced IL-6, TNF-a and MCP-1 BALF concentrations.
Reduced total cellular infiltrates in the lungs, characterised by significantly reduced neutrophils, macrophages and dendritic cells.
Chemical Information
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No. CAS 2757333-37-0
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Appearance Solid
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Peso molecular 403.53
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Fòrmula C22H29NO4S
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Color White to light yellow
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SMILES
O=C(CCCC1=CC=C(C2=CC=C(S(=O)(N(CCC)CCC)=O)C=C2)C=C1)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (4)
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Journal Impact Factor
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Most Recent
Solvente y solubilidad
DMSO : 100 mg/mL (247.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 12.5 mg/mL (30.98 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO | 1 mM | 2.4781 mL | 12.3907 mL | 24.7813 mL | 61.9533 mL |
| 5 mM | 0.4956 mL | 2.4781 mL | 4.9563 mL | 12.3907 mL | |
| 10 mM | 0.2478 mL | 1.2391 mL | 2.4781 mL | 6.1953 mL | |
| 15 mM | 0.1652 mL | 0.8260 mL | 1.6521 mL | 4.1302 mL | |
| 20 mM | 0.1239 mL | 0.6195 mL | 1.2391 mL | 3.0977 mL | |
| 25 mM | 0.0991 mL | 0.4956 mL | 0.9913 mL | 2.4781 mL | |
| 30 mM | 0.0826 mL | 0.4130 mL | 0.8260 mL | 2.0651 mL | |
| DMSO | 40 mM | 0.0620 mL | 0.3098 mL | 0.6195 mL | 1.5488 mL |
| 50 mM | 0.0496 mL | 0.2478 mL | 0.4956 mL | 1.2391 mL | |
| 60 mM | 0.0413 mL | 0.2065 mL | 0.4130 mL | 1.0326 mL | |
| 80 mM | 0.0310 mL | 0.1549 mL | 0.3098 mL | 0.7744 mL | |
| 100 mM | 0.0248 mL | 0.1239 mL | 0.2478 mL | 0.6195 mL |
ADS032 Related Classifications
HY-156798 Related Classifications
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