Amoscanate
Based on 1 Customer Validation
Amoscanate (cgp4540) is phenyl isothiocyanate in which the hydrogen at the para-position has been replaced by a 4-nitroanilinyl group. Amoscanate is an anti-schistosomal agent. Amoscanate, as an isothiocyanate compound and uncoupler of oxidative phosphorylation, potently injures rodent ependyma.
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- Pureza: 99.45%
- No. CAS: 26328-53-0
- Fòrmula: C13H9N3O2S
- Peso molecular:271.29
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
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Actividad biológica
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Schistosome |
Amoscanate (250 and 500 mg/kg; p.o.; 28 days) elicits necrosis, Ca++-positive microgranules, pyknosis and edema localized in ependyma/subependyma in the medial striatum[1].
Amoscanate (25~500 mg/kg; p.o.; 20 days) elicits progressive necrosis of ependyma[1].
Amoscanate elicits massive ultrastructural damage in ependymal cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats[1]
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Dosage:500 mg/kg
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Administration:P.o.; 10 days
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Result:Destructed ependyma and periventricular brain.
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Animal Model:Sprague-Dawley rats[1]
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Dosage:250 and 500 mg/kg
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Administration:P.o.; 28 days
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Result:Elicited necrosis, Ca++-positive microgranules, pyknosis and edema localized in ependyma/subependyma in the medial striatum.
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Animal Model:Sprague-Dawley rats[1]
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Dosage:25~500 mg/kg
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Administration:P.o.; 20 days
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Result:Elicited progressive necrosis of ependymal.
Chemical Information
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No. CAS 26328-53-0
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Appearance Solid
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Peso molecular 271.29
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Fòrmula C13H9N3O2S
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Color Yellow to orange
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SMILES
O=[N+]([O-])C(C=C1)=CC=C1NC2=CC=C(C=C2)N=C=S
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Synonyms
CGP4540
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvente y solubilidad
DMSO : 50 mg/mL (184.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6861 mL | 18.4305 mL | 36.8609 mL | 92.1523 mL |
| 5 mM | 0.7372 mL | 3.6861 mL | 7.3722 mL | 18.4305 mL | |
| 10 mM | 0.3686 mL | 1.8430 mL | 3.6861 mL | 9.2152 mL | |
| 15 mM | 0.2457 mL | 1.2287 mL | 2.4574 mL | 6.1435 mL | |
| 20 mM | 0.1843 mL | 0.9215 mL | 1.8430 mL | 4.6076 mL | |
| 25 mM | 0.1474 mL | 0.7372 mL | 1.4744 mL | 3.6861 mL | |
| 30 mM | 0.1229 mL | 0.6143 mL | 1.2287 mL | 3.0717 mL | |
| 40 mM | 0.0922 mL | 0.4608 mL | 0.9215 mL | 2.3038 mL | |
| 50 mM | 0.0737 mL | 0.3686 mL | 0.7372 mL | 1.8430 mL | |
| 60 mM | 0.0614 mL | 0.3072 mL | 0.6143 mL | 1.5359 mL | |
| 80 mM | 0.0461 mL | 0.2304 mL | 0.4608 mL | 1.1519 mL | |
| 100 mM | 0.0369 mL | 0.1843 mL | 0.3686 mL | 0.9215 mL |
Amoscanate Related Classifications
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