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Bleomycin

212 Cited Publications
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Based on 212 publication(s) in Google Scholar

Bleomycin is a glycopeptide antibiotic. Bleomycin has potent antitumour activities against a range of lymphomas, head and neck cancers and germ-cell tumours. Bleomycin can be used for the research of cancer and chemotherapy.

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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Bleomycin Chemical Structure
    Bleomycin Chemical Structure
  • Experimental Validation Results for Bleomycin
  • Experimental Validation Results for Bleomycin
  • Experimental Validation Results for Bleomycin
  • Experimental Validation Results for Bleomycin
  • Experimental Validation Results for Bleomycin
  • Experimental Validation Results for Bleomycin
  • Experimental Validation Results for Bleomycin
  • Experimental Validation Results for Bleomycin
  • Experimental Validation Results for Bleomycin
  • Experimental Validation Results for Bleomycin
  • Experimental Validation Results for Bleomycin
No. CAS: 11056-06-7
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  • Bleomycin Chemical Structure
    Bleomycin Chemical Structure
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    Bleomycin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Aug:131:155797. [Abstract]

    Customer Validation
     PCF-EtOH diminished BLM (Bleomycin sulfate)-induced increase of fibronectin, vimentin and α-SMA. All mice, except those in the control group (nebulization with saline), are nebulised with BLM/saline (1 mg/mL, 8 mL) for 30 min on days 1, 4 and 7, respectively.

  • 1/16

    Bleomycin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Aug:131:155797. [Abstract]

    Customer Validation
     PCF-EtOH blocked BLM (Bleomycin sulfate)-induced upregulation of β-catenin protein. All mice, except those in the control group (nebulization with saline), are nebulised with BLM/saline (1 mg/mL, 8 mL) for 30 min on days 1, 4 and 7, respectively.

  • 1/16

    Bleomycin purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2024 Apr 18;81(1):187. [Abstract]

    Customer Validation
     Bleomycin sulfate (3 mg/kg; nebulized) significantly upregulates TRPA1 protein levels in mice.​

  • 1/16

    Bleomycin purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2024 Apr 18;81(1):187. [Abstract]

    Customer Validation
     Bleomycin sulfate (3 mg/kg; nebulized) significantly increases TRPA1 mRNA levels in mouse lung tissues.​

  • 1/16

    Bleomycin purchased from MedChemExpress. Usage Cited in: Mech Ageing Dev. 2024 Apr:218:111902. [Abstract]

    Customer Validation
     miR-129 delays bleomycin-induced cellular senescence. MRC5 cells were transfected with miR-Ctrl or miR-129 and then treated with bleomycin (1 µg/ml) where indicated. Four days after transfection, the p-H2AX, ITPR2, p16, p21 and GAPDH protein levels were quantified by western blot.

  • 1/16

    Bleomycin purchased from MedChemExpress. Usage Cited in: Sci China Life Sci. 2023 Nov;66(11):2571-2586. [Abstract]

    Customer Validation
     Bleomycin (1 mg/kg; single intratracheal injection). Results for time-course Western blot analysis of Plekhf1 and Arg1 (a macrophage M2 marker) and Col 1α (a fibrotic marker) expression in lung macrophages isolated from BLM-treated mice. Left panel: Representative Western blot images. Right panel: Bar graphs showing the data from three replicates.

  • 1/16

    Bleomycin purchased from MedChemExpress. Usage Cited in: Sci China Life Sci. 2023 Nov;66(11):2571-2586. [Abstract]

    Customer Validation
     Bleomycin (1 mg/kg; single intratracheal injection). Representative results of coimmunostaining for Plekhf1 and F4/80 in lung sections.

  • 1/16

    Bleomycin purchased from MedChemExpress. Usage Cited in: Sci China Life Sci. 2023 Nov;66(11):2571-2586. [Abstract]

    Customer Validation
     Bleomycin (1 mg/kg; single intratracheal injection). Representative results of coimmunostaining for Plekhf1 and F4/80 in BALF cells from BLM-treated mice.

  • 1/16

    Bleomycin purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Nov 13;11(11):978. [Abstract]

    Customer Validation
     Bleomycin (BLM) (5 mg/kg; intratracheal instillation) significantly elevated the ratio of phosphorylated p65 to total p65 (p-p65/p65) and reduced the expression level of IκBα, indicating that NF-κB signaling pathway was activated in BLM-induced pulmonary fibrosis.

  • 1/16

    Bleomycin purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Nov 13;11(11):978. [Abstract]

    Customer Validation
     Bleomycin (BLM) (5 mg/kg; intratracheal instillation) increases the expression of NLRP3 in BALB/c mice.

  • 1/16

    Bleomycin purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Nov 13;11(11):978. [Abstract]

    Customer Validation
     Bleomycin (BLM) (5 mg/kg; intratracheal instillation) upregulates the mRNA levels of NLRP3, ASC, IL-1β, and IL-18 in BALB/c mice.

  • Bleomycin