BOLD-100
Based on 1 publication(s) in Google Scholar
BOLD-100 (NKP-1339; IT-139) is the first-in-class ruthenium-based anticancer agent in development against solid cancer with limited side effects. BOLD-100 induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway. BOLD-100 has a high tumor targeting potential, strongly binds to serum proteins such as albumin and transferrin and activates in the reductive tumor milieu.
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- Pureza: 95.20%
- No. CAS: 197723-00-5
- Fòrmula: C14H12Cl4N4NaRu
- Peso molecular:502.14
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) BOLD-100
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Actividad biológica
BOLD-100 (0-200 μM; 72 hours) has the anticancer activity against malignant cell lines of diverse origin, exhibits IC50 values of 45-200 μM for KP1339 mono-therapy. It against Hepatoma cell line, Hep3B, HepG2, PLC/PRF/5 and HCC2 cells with the Mean IC50 value of 186.3 μM, 165.4 μM, 124.4 μM, and 69.4 μM, respectively. It against Melanoma cell line, VM-1, VM-21,VM-48 with IC50 values of 178 μM, 111 μM, and 143 μM, respectively. It against Lung cancer and Colon cancer cell lines, inhibits A549, VL-8, SW480 and HCT116 cells, respectively[2].BOLD-100 (0-150 μM; 24 hours) induces cell apoptosis alone. When it combines with sorafenib, it increases the numbers of the apopotic cells. Additionally, the p-PARP and caspase 7 cleavage is promoted either[2].BOLD-100 (0-150 μM; 24 hours) can promote phosphorylation of STAT3 and CREB expression, however, the decreasation is inhibited by sorafenib cotreatment[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Hepatoma, Melanoma, Lung cancer and Colon cancer cell lines
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Concentration:0 μM, 50 μM, 100 μM, 150 μM and 200 μM
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Incubation Time:72 hours
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Result:Has anti-cancer activity in diverse malignant tumour cell types.
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Cell Line:Hep3B cells
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Concentration:0 μM, 75 μM, 150 μM
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Incubation Time:72 hours
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Result:Promoted cell apoptosis as a concentration manner.
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Cell Line:Hep3B cells
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Concentration:0 μM, 75 μM, 150 μM
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Incubation Time:72 hours
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Result:Increased p-STAT3 and p-CREB expression in cells without sorafenib cotreatment.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Hep3B xenograft in Balb/c mice[2]
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Dosage:30 mg/kg
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Administration:Intravenous injection
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Result:Had synergistic activity of KP1339 with sorafenib in vivo.
Chemical Information
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No. CAS 197723-00-5
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Appearance Solid
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Peso molecular 502.14
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Fòrmula C14H12Cl4N4NaRu
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Color Brown to dark brown
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SMILES
[Cl-][Ru+3]([Cl-])([Cl-])([N]1=CC2=C(N1)C=CC=C2)([N]3=CC4=C(N3)C=CC=C4)[Cl-].[Na+]
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Synonyms
NKP-1339; IT-139; KP-1339
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvente y solubilidad
DMSO : ≥ 59 mg/mL (117.50 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (285 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9915 mL | 9.9574 mL | 19.9148 mL | 49.7869 mL |
| 5 mM | 0.3983 mL | 1.9915 mL | 3.9830 mL | 9.9574 mL | |
| 10 mM | 0.1991 mL | 0.9957 mL | 1.9915 mL | 4.9787 mL | |
| 15 mM | 0.1328 mL | 0.6638 mL | 1.3277 mL | 3.3191 mL | |
| 20 mM | 0.0996 mL | 0.4979 mL | 0.9957 mL | 2.4893 mL | |
| 25 mM | 0.0797 mL | 0.3983 mL | 0.7966 mL | 1.9915 mL | |
| 30 mM | 0.0664 mL | 0.3319 mL | 0.6638 mL | 1.6596 mL | |
| 40 mM | 0.0498 mL | 0.2489 mL | 0.4979 mL | 1.2447 mL | |
| 50 mM | 0.0398 mL | 0.1991 mL | 0.3983 mL | 0.9957 mL | |
| 60 mM | 0.0332 mL | 0.1660 mL | 0.3319 mL | 0.8298 mL | |
| 80 mM | 0.0249 mL | 0.1245 mL | 0.2489 mL | 0.6223 mL | |
| 100 mM | 0.0199 mL | 0.0996 mL | 0.1991 mL | 0.4979 mL |
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