CD28-IN-4
CD28-IN-4 is a selective CD28 inhibitor with a human IC50 of 231 nM and a human Kd of 344 nM. CD28-IN-4 binds to CD28, disrupts its interaction with CD80, blocks CD28-mediated co-stimulatory signal transduction, and reduces cytokine secretion in a human primary tumor-PBMC and epithelial tissue co-culture model. CD28-IN-4 can be used for cancer-related research.
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- No. CAS: 3116073-35-6
- Fòrmula: C19H20ClN5O3
- Peso molecular:401.85
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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IL-2 |
TNF-α |
CD28-IN-4 (100 μM; 15 min) interacts directly with purified recombinant human CD28 extracellular domain at a concentration of 100 μM, as measured by the Dianthus TRIC assay[1].
CD28-IN-4 (1-10 μM; 48 h) suppresses CD28-dependent T cell activation in a 3D coculture of A549 tumor spheroids and primary human PBMCs, reducing IFN-γ, IL-2, and soluble CD69 levels in a concentration-dependent manner at 1, 5, and 10 μM over 48 h[1].
CD28-IN-4 (1-10 μM; 48 h) inhibits CD28-mediated cytokine production in a coculture of differentiated human MucilAir airway epithelial tissue and primary human PBMCs, reducing IFN-γ, IL-2, and TNF-α levels in a concentration-dependent manner at 1, 5, and 10 μM over 48 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:3D coculture of A549 tumor spheroids and primary human PBMCs
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Concentration:1, 5, 10 μM
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Incubation Time:48 h
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Result:Suppressed CD28-dependent T cell activation in a 3D coculture of A549 tumor spheroids and primary human PBMCs.
Reduced IFN-γ, IL-2, and soluble CD69 levels in a concentration-dependent manner.
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Cell Line:differentiated human MucilAir airway epithelial tissue and primary human PBMCs
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Concentration:1, 5, 10 μM
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Incubation Time:48 h
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Result:Inhibited CD28-mediated cytokine production in a coculture of differentiated human MucilAir airway epithelial tissue and primary human PBMCs.
Reduced IFN-γ, IL-2, and TNF-α levels in a concentration-dependent manner.
Chemical Information
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No. CAS 3116073-35-6
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Peso molecular 401.85
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Fòrmula C19H20ClN5O3
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SMILES
ClC1=CN2C(C=C1)=CC(C(N3CC(CN4C=C(CCC(O)=O)N=N4)CC3)=O)=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CD28-IN-4 Related Classifications
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