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Referencia número: HY-P990981

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Clesitamig

Name: Clesitamig
Brand: MedChemExpress
SKU: HY-P990981
Price: 700.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: ALPS-12; RG-6524; RO 7616789)

Revisión del cliente

Based on 1 Customer Validation

Clesitamig (ALPS-12) is a trispecific T cell engager with two CD3/CD137 dual-specific Fabs and one DLL3 Fab. Clesitamig engages CD3 and CD137 on T cells to activate and co-stimulate T cells, promoting their proliferation, survival, and antitumor activity. Clesitamig binds to DLL3 on tumor cells for tumor-specific recognition. Clesitamig can be used for the research of small cell lung cancer (SCLC).

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 99.78%
No. CAS: 2930861-48-4
Peso molecular:195.836 kDa

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Clesitamig Chemical Structure

No. CAS: 2930861-48-4

Tamaño

Precio

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Ensayo clínico
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Aplicación
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Isotype

Fab-kappa_crossover-IgG1-kappa_tetrekisdisulfide

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

CD3E & TNFRSF9 & DLL3

In Vitro

Clesitamig successfully engages its targets to activate CD3 and CD137 signaling, as demonstrated by a dose-dependent increase in NFAT and NF-κB activity in Jurkat reporter cells cocultured with DLL3-positive cells^[2].
Clesitamig induces cytotoxicity against SCLC cell lines co-cultured with human PBMCs, with EC₅₀ values in the two-digit picomolar range^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Clesitamig inhibits tumor growth in mouse SCLC xenograft models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ensayo clínico

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

10683 [NCBI]

Accession

Q9NYJ7

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Fab-kappa_crossover-IgG1-kappa_tetrekisdisulfide

Aplicación

ELISA, FACS, Functional assay

Chemical Information

No. CAS 2930861-48-4
Appearance Liquid
Peso molecular 195.836 kDa
Color Colorless to light yellow
SMILES

[Clesitamig]
Synonyms

ALPS-12; RG-6524; RO 7616789
Envío

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (257 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Referencias

[1]. Kang J, et al. Immune cell engagers in lung cancer. Front Immunol. 2026 Apr 10;17:1746093. [Content Brief]

[2]. Hirofumi Mikami, et al. Abstract 1872: A DLL3/CD3/CD137 trispecific T cell engager shows potent antitumor activity in small cell lung cancer models. Cancer Res (2023) 83 (7_Supplement): 1872.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Actividad biológica
- Descripciòn
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Ensayo clínico
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Aplicación
Chemical Information
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

Clesitamig

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)

PBS Buffer (1×)