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Referencia número: HY-164413

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CLM3

CLM3, a pyrazolopyrimidine derivative, is a multiple tyrosine kinase inhibitor. CLM3 shows antiproliferative and proapoptotic activity on endothelial and cancer cells, synergistically enhanced by SN38 (HY-13704). These effects are mainly due to its inhibition of phosphorylation of VEGFR-2, EGFR and RET tyrosine kinases and their related signaling pathways.

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No. CAS: 1312024-59-1
Fòrmula: C₂₁H₂₁N₅
Peso molecular:343.42

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CLM3 Chemical Structure

No. CAS: 1312024-59-1

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Actividad biológica

Descripciòn

IC₅₀ & Target

VEGFR2

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Cellular Effect

Cell Line	Type	Value	Description	References
8305C	IC₅₀	9.2 μM Compound: CLM3	Antiproliferative activity against human 8305C cells expressing RET after 72 hrs Antiproliferative activity against human 8305C cells expressing RET after 72 hrs	[PMID: 24447248]
TT	IC₅₀	26.93 μM Compound: CLM3	Antiproliferative activity against human TT cells Antiproliferative activity against human TT cells	[PMID: 24447248]

In Vitro

CLM3 (0-100 μM, 72 h) significantly decreases phospho-VEGFR-2, phospho-EGFR and phospho-RET levels in activated endothelial and cancer cells^[1].
CLM3 (0-100 μM, 72 h) greatly inhibits the expression of the cyclin D1 gene in endothelial and cancer cells, decreasing the cyclin D1 protein intracellular concentration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 1312024-59-1
Peso molecular 343.42
Fòrmula C₂₁H₂₁N₅
SMILES

C[C@@H](NC1=C2C(N(CCC3=CC=CC=C3)N=C2)=NC=N1)C4=CC=CC=C4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Bocci G, et al. Antiproliferative and proapoptotic activity of CLM3, a novel multiple tyrosine kinase inhibitor, alone and in combination with SN-38 on endothelial and cancer cells. Biochem Pharmacol. 2011 Jun 1;81(11):1309-16. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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CLM3

Ver todos los productos específicos de isoformas VEGFR

Ver todos los productos específicos de isoformas EGFR

Actividad biológica

Chemical Information

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CLM3 Related Classifications

HY-164413 Related Classifications