CPN4F
CPN4F is a chalcone derivative with antiparasitic activity. CPN4F is an inhibitor of the cysteine protease cruzain. CPN4F forms a key hydrogen bond with the Trp-184 residue in the active site of parasitic cruzain as an electrophile, and induces oxidative stress, cell membrane degradation, and necrosis, thereby inhibiting parasite proliferation. CPN4F is used in research related to Chagas disease.
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- Fòrmula: C18H17FO5
- Peso molecular:332.32
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
Trypanosoma |
cathepsin L |
In Vitro
CPN4F (15.6-1000 μM; 24-72 h) exerts potent antiproliferative effects on epimastigotes of T. cruzi strain Y, with IC50 values of 356.70 μM, 149.30 μM, and 22.95 μM at 24 h, 48 h, and 72 h, respectively[1].
CPN4F (31.2-1000 μM; 24 h) exhibits excellent trypanocidal activity against trypomastigotes of T. cruzi strain Y, with an LC50 of 32.54 μM[1].
CPN4F (15.6-1000 μM; 24 h) exhibits significant cytotoxicity in LLC-MK2 host cells, causing a concentration-dependent decrease in cell viability, with a CC50 of 99.26 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LLC-MK2 cells
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Concentration:15.6, 31.2, 62.5, 125, 250, 500, 1000 μM
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Incubation Time:24 h
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Result:Exhibited significant host cell toxicity.
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Cell Line:Epimastigote forms of T. cruzi strain Y
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Concentration:15.6, 31.2, 62.5, 125, 250, 500, 1000 μM
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Incubation Time:24 h, 48 h, 72 h
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Result:Demonstrated time- and concentration-dependent antiproliferative effects on epimastigotes.
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Cell Line:Trypomastigote forms of T. cruzi strain Y
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Concentration:31.2, 62.5, 125, 250, 500, 1000 μM
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Incubation Time:24 h
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Result:Effectively killed the trypomastigotes with LC50 of 32.54 μM.
Chemical Information
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Peso molecular 332.32
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Fòrmula C18H17FO5
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SMILES
O=C(C1=C(OC)C=C(OC)C(OC)=C1O)/C=C/C2=CC=C(F)C=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CPN4F Related Classifications
HY-189048 Related Classifications
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