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Referencia número: HY-114215

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DSM-421

DSM-421 is an orally active Dihydroorotate dehydrogenase inhibitor. DSM-421 has antiplasmodium activity.

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No. CAS: 2011769-21-2
Fòrmula: C₁₄H₁₁F₅N₆
Peso molecular:358.27

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

DSM-421 Chemical Structure

No. CAS: 2011769-21-2

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Actividad biológica

Descripciòn

DSM-421 is an orally active Dihydroorotate dehydrogenase inhibitor. DSM-421 has antiplasmodium activity^[1].

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In Vivo

DSM-421 (0.1-30 mg/kg orally for 4 consecutive days) has strong antimalarial activity in a SCID mouse model of Plasmodium falciparum ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2011769-21-2
Peso molecular 358.27
Fòrmula C₁₄H₁₁F₅N₆
SMILES

FC(F)(C1=NC=C(NC2=CC(C)=NC3=NC(C(F)(C)F)=NN32)C=C1)F
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Phillips MA, et al. A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria. ACS Infect Dis. 2016 Dec 9;2(12):945-957. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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DSM-421

Ver todos los productos específicos de isoformas Parasite

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Referencias

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DSM-421 Related Classifications

HY-114215 Related Classifications