Spiro-duocarmycin
Spiro-duocarmycin is a DNA minor groove N3-adenine alkylating agent. Spiro-duocarmycin exerts cytotoxic effects via DNA alkylation. Spiro-duocarmycin is the active spirocyclized form of seco-DUBA, which is incorporated as an inactive prodrug into the linker-drug construct of antibody-drug conjugates (ADCs). DUBA serves as an ADC payload that can be conjugated with monoclonal antibodies to synthesize antibody-drug conjugates (ADCs).
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- No. CAS: 1642147-15-6
- Fòrmula: C29H22N4O4
- Peso molecular:490.51
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Spiro-duocarmycin (DUBA; Compound 3b) potently inhibits the viability of human breast cancer SK-BR-3 cells, with an IC50 of 0.07 nM, and its efficacy is comparable to that of its precursor seco-DUBA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | T1/2 | CL |
|---|---|---|---|---|
| Rat[1] | 0.083 mg/kg | i.v. | 1.1 h | 17 L/h/kg |
Chemical Information
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No. CAS 1642147-15-6
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Peso molecular 490.51
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Fòrmula C29H22N4O4
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SMILES
O=C(C1=CN2C(C=CC(NC(C3=CC=C(C=C3)O)=O)=C2)=N1)N4C([C@@]5(C6=C(C)C=CC=C67)[C@](C4)([H])C5)=CC7=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Spiro-duocarmycin Related Classifications
HY-160969 Related Classifications
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