FGA145
FGA145 is a dual, selective inhibitor for Mpro and human Cathepsin L, with Kis of 3.71 μM, 9.82 μM and 53 nM, for Mal-Mpro, pET21-Mpro and Cathepsin L, respectively. FGA145 reveals a multitarget effects in the antiviral activity.
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- Fòrmula: C23H30N4O5
- Peso molecular:442.51
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Actividad biológica
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Chemical Information
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Actividad biológica
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cathepsin L 53 nM (Ki) |
Cathepsin B 206 nM (Ki) |
FGA145 reveals weak antiviral activity against SARS-CoV-2 with EC50 of 11.7 μM with low cytotoxicity in Huh-7-ACE2 cells (CC50 over 100 μM)[1].
FGA145 exhibits inhibitory properties towards cysteine proteases RhD, CRZ, Cat L and Cat B, with Kis of 1.63, 12.6, 53 and 206 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Huh-7-ACE2
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Concentration:0-100 μM
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Incubation Time:24 h
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Result:Exhibited a CC50 of over 100 μM.
Chemical Information
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Peso molecular 442.51
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Fòrmula C23H30N4O5
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SMILES
O=C(N[C@@H](C[C@@H]1CCNC1=O)/C=C/[N+]([O-])=O)[C@H](CC(C)C)NC(/C=C/C2=CC=CC=C2)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FGA145 Related Classifications
HY-161244 Related Classifications
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