Gem-C12
Based on 1 Customer Validation
Gem-C12 is a prodrug of Gemcitabine (HY-17026). Gem-C12 terminates DNA chain elongation, inhibits nucleic acid synthesis and induces Apoptosis. Gem-C12 inhibits the proliferation of glioma cells. Gem-C12 and Honokiol (HY-N0003) exhibit synergistic anti-glioblastoma activity. Gem-C12 can be used in research related to glioblastoma multiforme.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.48%
- No. CAS: 849139-19-1
- Fòrmula: C21H33F2N3O5
- Peso molecular:445.50
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Gem-C12 (24 h) inhibits glioblastoma U87 cell viability with an IC50 of 15.74 μM after 24 h of incubation[1].
Free Gem-C12 combined with HNK at a 1:1 mole ratio (24 h) inhibits human glioblastoma U87 cell viability with a Gem-C12 IC50 of 8.75 μM and a synergistic CI of 0.78 after 24 h of incubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Cmax | AUC0-∞ | T1/2 |
|---|---|---|---|---|---|
| Rat[1] | 8.5 μmol/Kg | i.v. | 1250 ± 187 ng/mL | 801 ng·h/mL | 1.14 h |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 849139-19-1
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Appearance Solid
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Peso molecular 445.50
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Fòrmula C21H33F2N3O5
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Color White to off-white
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SMILES
O=C1N=C(NC(CCCCCCCCCCC)=O)C=CN1[C@H]2C(F)(F)[C@H](O)[C@@H](CO)O2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 35 mg/mL (78.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2447 mL | 11.2233 mL | 22.4467 mL | 56.1167 mL |
| 5 mM | 0.4489 mL | 2.2447 mL | 4.4893 mL | 11.2233 mL | |
| 10 mM | 0.2245 mL | 1.1223 mL | 2.2447 mL | 5.6117 mL | |
| 15 mM | 0.1496 mL | 0.7482 mL | 1.4964 mL | 3.7411 mL | |
| 20 mM | 0.1122 mL | 0.5612 mL | 1.1223 mL | 2.8058 mL | |
| 25 mM | 0.0898 mL | 0.4489 mL | 0.8979 mL | 2.2447 mL | |
| 30 mM | 0.0748 mL | 0.3741 mL | 0.7482 mL | 1.8706 mL | |
| 40 mM | 0.0561 mL | 0.2806 mL | 0.5612 mL | 1.4029 mL | |
| 50 mM | 0.0449 mL | 0.2245 mL | 0.4489 mL | 1.1223 mL | |
| 60 mM | 0.0374 mL | 0.1871 mL | 0.3741 mL | 0.9353 mL |
Gem-C12 Related Classifications
HY-185323 Related Classifications
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